Identification and Characterization of Novel Bioactive Peptides from Australian Conesnails targeting Pain Pathways

澳大利亚锥螺中针对疼痛通路的新型生物活性肽的鉴定和表征

• 批准号: nhmrc : 569918
• 负责人: Dr Irina Vetter
• 金额: $ 21.39万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-characterization-novel-pain-pathways/116142
• 关键词: Identification; Characterization; Novel; Bioactive; Peptides

In recent years, significant advances have been made in the identification of new targets in the central or peripheral nervous systems which may be used to develop new pain killers. However, molecules specifically targeting these receptors and channels are lacking to date. This project will use novel cell-based approaches to find new molecules from conesnails which specifically target receptors involved in pain. These will be useful to increase our understanding of the mechanisms of pain.

近年来，在确定中枢或外周神经系统中的新靶点方面取得了重大进展，这些新靶点可用于开发新的止痛药。然而，迄今为止缺乏特异性靶向这些受体和通道的分子。该项目将使用新的基于细胞的方法从锥钉中发现新的分子，这些分子专门针对与疼痛有关的受体。这些将有助于增加我们对疼痛机制的理解。