Novel analgesic approaches: harnessing functional interactions between sodium channels and opioids

新型镇痛方法：利用钠通道和阿片类药物之间的功能相互作用

• 批准号: nhmrc : 1125766
• 负责人: Dr Irina Vetter
• 金额: $ 22.45万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-analgesic-approaches-channels-opioids/947659
• 关键词: Novel; analgesic; approaches; harnessing; functional

Chronic pain is a debilitating condition that affects the life of one five Australians and has significant socioeconomic impact. Currently available pain killers often do not work, or have intolerable side effects. We have discovered that combination treatment with opioids and a novel venom-derived compound discovered by us provides effective pain relief. The aim of this project is to understand the mechanisms underlying this synergistic effect to develop new treatment approaches for pain.

慢性疼痛是一种使人衰弱的疾病，影响了五分之一澳大利亚人的生活，并具有重大的社会经济影响。目前可用的止痛药往往不起作用，或有无法忍受的副作用。我们发现，阿片类药物和我们发现的一种新型毒液衍生化合物的联合治疗可有效缓解疼痛。该项目的目的是了解这种协同效应的机制，以开发新的疼痛治疗方法。