Advance Veterinary Services

加尔维斯顿国家实验室高级兽医服务（GAVS）核心的主要功能是 支持加尔维斯顿国家实验室（GNL）的生物防御和新兴传染病使命 疾病核心将提供研究支持服务，以及培训，以维持一个高技能 具有动物模型开发、宿主-病原体关系和 用于测试疫苗和治疗剂对抗气溶胶攻击。该设施旨在提供最大限度的 灵活性，并将纳入BSL-2/3/4实验室，与支持动物研究实验室， 空气生物学套房，小动物和非人类灵长类动物的饲养室，尸检室，以及相关的 支持空间。然而，我们认识到需要补充或取代涉及动物的研究， 尽可能采用科学有效的替代方法，并最大限度地利用 这样的研究。我们决定建立和利用一个高效熟练的兽医核心设施， 因此，在很大程度上是基于我们努力限制动物物种的数量和种类。 技术包括手术植入遥测装置、腹腔镜、内窥镜和超声 引导的组织活检将用于通过微创技术提供真实的时间数据。核心 将随时访问和专门设计，装备，管理和操作，作为一个高度 有效的国家资源，为NIAID的生物防御网络和其他联邦和非联邦 支持生物防御和新兴感染研究项目。在发生国家生物恐怖主义或 新出现的疾病紧急情况，拟议的GAVS核心将提供激增的实验室能力， 实验室人员、诊断和专家咨询，为地方、地区、州和国家实体提供服务 参与第一反应和生物事件管理。GAVS核心主任，与 GNL的行政核心将指导所有活动并确定其优先次序，以协助NIAID资助的 来自缺乏适当生物防护设施、技术和/或 训练

The primary function of the Galveston National Laboratory Advanced Veterinary Services (GAVS) Core is to support the Galveston National Laboratory's (GNL) mission on Biodefense and Emerging Infectious Diseases. The core will provide research support services, as well as training to sustain a highly skilled cadre of personnel with expertise on the development of animal models, host-pathogen relationships, and for testing of vaccines and therapeutics against aerosol challenge. The facility is designed to offer maximum flexibility, and will incorporate BSL-2/3/4 laboratories, with supporting animal research laboratories, aerobiology suites, a vivarium for small animals and non-human primates, necropsy room, and associated support spaces. However, we recognize the need to supplement or replace studies involving animals with alternative, scientifically valid approaches wherever possible, and to maximize the information gained from such studies. Our decision to establish and utilize a highly efficient skilled veterinary core facility was therefore based to a large extent on our efforts to limit the number and variety of animal species. Technologies including surgically implanted telemetric devices, laproscopic, endoscopic, and ultrasound guided tissue biopsies will be used to provide real time data with minimally invasive techniques. The core will be readily accessible and specifically designed, equipped, managed and operated to serve as a highly efficient national resource for the NIAID's Biodefense Network and other federally and non-federally supported biodefense and emerging infections research programs. In the event of a national bioterrorism or emerging disease emergency, the proposed GAVS Core will offer surge laboratory capacity, trained laboratory personnel, diagnostic, and expert consultation to local, regional, state, and national entities involved in first response and biological incident management. The GAVS Core Director, in consultation with the GNL administrative core will direct and prioritize all activities with the aim of assisting NIAID-funded biodefense investigators from institutions lacking appropriate biocontainment facilities, technology, and/or training.