Identification and characterization of a novel tumor suppressor

点击翻译按钮获取中文摘要

Australia has the highest rate of skin cancer in the world, with over 380,000 people diagnosed every year. Of these, over 370,000 have non-melanoma skin cancers including squamous cell carcinoma and basal cell carcinoma. Our laboratory has identified a gene in mice that protects animals from squamous cell cancer. The studies proposed in this grant examine the mechanisms underpinning this protective role and may have important implications for the prevention of skin cancers in humans.