Analysis of factors governing globin gene expression

珠蛋白基因表达的影响因素分析

• 批准号: nhmrc : 489411
• 负责人: Prof John Cunningham
• 金额: $ 34.21万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/analysis-factors-governing-gene-expression/77465
• 关键词: Analysis; factors; governing; globin; gene

Hemoglobin is the major protein in red blood cells and is essential for the transport of oxygen from the lungs to the tissues. The disorders of hemoglobin production are the commonest genetic diseases world-wide. These diseases can be markedly improved with elevation of the form of hemoglobin produced by the developing embryo, fetal hemoglobin. We have identified key factors important for fetal gene expression. Our goal is to translate these findings into therapies for the hemoglobin disorders.

血红蛋白是红细胞中的主要蛋白质，并且对于将氧气从肺运输到组织是必不可少的。血红蛋白生成障碍是世界范围内最常见的遗传性疾病。这些疾病可以显着改善与升高的形式所产生的血红蛋白的发展胚胎，胎儿血红蛋白。我们已经确定了胎儿基因表达的关键因素。我们的目标是将这些发现转化为血红蛋白紊乱的治疗方法。