Defects in epidermal morphogenesis in Grainyhead-like gene deficient mice

皮肤细胞在哺乳动物胚胎的发育中起着至关重要的作用。它们对于形成抵抗感染和外部毒素的保护性屏障、防止多余的液体流失、修复缺陷和伤口以及生成毛发至关重要。我们的实验室已经确定了一个对这些过程至关重要的基因家族。这项研究的目的是确定这些基因之间的关系，以加深我们对皮肤及其功能的理解

The cells of the skin play an essential role in the development of the mammalian embryo. They are critical for forming a protective barrier against infection and external toxins, for preventing excess fluid loss, for repair of defects and wounds , and for the generation of hair. Our laboratory has identified a family of genes that are critical for these processes. The aim of this study is to determine the relationship between these genes to further our understanding of the skin and its functions