Nanoparticle Formation and Biodistribution for Optimizing Therapy

在过去的十年里，癌症化疗取得了重大进展，但针对特定靶点和 在癌症治疗中，有效的药物输送机制仍然是一个未得到满足的需求。此应用程序 代表着化学和医学专业知识的独特组合，将使开发和 测试新的药物输送方法。该化学方法在制备过程中使用二氧化碳作为溶剂 纳米颗粒的大小、形状和环境可以很好地控制，用于开发新的 用于成像的药物和分子传感器。纳米粒子将由小分子组成 (药物)，以及在需要时，用于受控释放和释放的聚合物包衣。这些纳米尺寸的药物将 允许靶向递送到例如癌细胞，允许使用较低剂量的药物，因此将 还减少了不必要的副作用和对健康细胞的损害。 具体目标是： 1.开发超临界抗溶剂工艺，以形成尺寸可控的微囊化纳米颗粒 形态学。 2.在超临界抗溶剂中原位包裹选定的纳米粒子。 3.在动物模型中评估选定的纳米颗粒 LAV摘要： 超临界抗溶剂合成提供了一种制造各种含量、尺寸的纳米颗粒的方法 和涂层。通过形成具有定制涂层的含有药物的纳米颗粒，将有可能靶向 将药物输送到体内特定的目的地。一个好处可能是一种新的化疗形式，其成本要低得多 患者的药物剂量和较低的副作用。

Significant advances in cancer chemotherapy have occurred over the last decade, but target-specific and effective drug delivery mechanisms remain an unmet need in the treatment of cancer. This application represents a unique combination of expertise in chemistry and medicine that will enable the development and testing of novel drug delivery approaches. The chemistry utilizes carbon dioxide as a solvent in the preparation of nanoparticles whose size, shape, and surroundings can be well-controlled for use in the development of new Pharmaceuticals and molecular sensors for imaging. The nanoparticles will be comprised of small molecules (drugs) and, when needed, a polymer coating for controlled delivery and release. These nanosized drugs will allow for targeted delivery to, e.g., a cancer cell, allowing for lower doses of drugs to be used and therefore will also reduced unwanted side-effects and damage to healthy cells. The Specific Aims are: 1. Develop a supercritical antisolvent process to form encapsulated nanoparticles of controlled size and morphology. 2. Encapsulate selected nanoparticles in situ in the supercritical antisolvent. 3. Evaluate selected nanoparticles in animal models Lav Summary: Supercritical antisolvent synthesis provides a way to create nanoparticles with a wide variety of contents, sizes and coatings. By forming nanoparticles containing drugs with custom coatings, it will be possible to target drugs to specific destinations in the body. One benefit may be a new form of chemotherapy with much lower dosages of drugs and lower side effects in the patient.