Novel Liquid Adhesive Bandages for Acceleration of Partial-Thickness Wound Healin

用于加速部分厚度伤口愈合的新型液体创可贴

• 批准号: 7392923
• 负责人: Ann Beal Salamone
• 金额: $ 10万
• 依托单位: ROCHAL INDUSTRIES, LLP
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392923
• 关键词: Acceleration; Adhesions; Adhesives; Bandage; Body Temperature; Burn injury; Caring; Cells; Class; Cutaneous; Depth; Dermatology; Drug Formulations; Evaluation; Family suidae; Fibroblasts; Film; Generations; Government; Growth; Healed; Hospital Nursing; Human; Hydrocolloid; Hydrogels; In Vitro; Industry; Infection; Inflammation; Inflammatory; Inflammatory Response; Laboratories; Laboratory Research; Licensing; Liquid substance; Modeling; Molecular Weight; Nitrogen; Nursing Homes; Occlusive Dressings; Operative Surgical Procedures; Oxygen; Permeability; Personal Satisfaction; Persons; Phase; Polymers; Process; Property; Protocols documentation; Purpose; Research; Sister; Skin; Small Business Innovation Research Grant; Solvents; Sterile coverings; Sting Injury; Supporting Cell; Surface; Sus scrofa; Testing; Thick; Time; Universities; Water; Wound Healing; aqueous; base; cell growth; commercialization; copolymer; evaporation; healing; improved; keratinocyte; monomer; novel; professor; scaffold; success; transmission process; vapor; wound

DESCRIPTION (provided by applicant): This Small Business Innovation Research (SBIR) Phase I project for Rochal Industries, LLP is to develop feasibility of a novel liquid adhesive bandage for assisting partial-thickness wound healing. This new class of liquid adhesive bandage forms a semi-occlusive, conformable, adherent polymer film on dry and moist surfaces that is non-stinging and non-burning, as well as oxygen- and water vapor-permeable. In vitro preliminary studies have shown that certain of these liquid bandages yielded clear, water-insoluble films that served as a scaffold for growth of human epidermal keratinocytes and human skin fibroblasts. It is the intent of this proposal to determine which novel liquid adhesive bandage composition is most efficacious in providing the greatest acceleration of partial-thickness wound healing. No commercially available, intimately conforming, liquid adhesive bandage has been shown to support cell growth as a means of wound healing. The unique polymer coatings of this research could have a major impact on their use in wound care dressings. The Wound Healing & Infection Research Laboratories of the Department of Dermatology & Cutaneous Surgery of the University of Miami will conduct inflammatory assessment and wound healing protocols on a pig model for deep partial-thickness wounds based upon the preferred liquid adhesive bandage formulations provided. This pig model has been used and validated on numerous wound care products, including hydrocolloids, hydrogels, transparent films, and occlusive dressings. The optimized formulation will be considered for Phase II testing. Rochal Industries, Inc., a sister company of Rochal Industries, LLP, previously invented a siloxanyl-based liquid adhesive bandage that was licensed and commercialized by 3M Company (3M Cavilon No Sting Barrier Film, for hospital and nursing homes, and 3M Nexcare Spray Liquid Bandage No Sting, for OTC). Although the commercialized bandage does not have the unique properties of the currently proposed bandages, the current company is well acquainted with the process of commercialization through licensing.

描述（由申请人提供）：Rochal Industries，LLP的小型企业创新研究（SBIR）第一阶段项目旨在开发一种新型液体粘性绷带的可行性，以帮助部分厚度伤口愈合。这种新型液体粘性绷带在干燥和潮湿的表面上形成半封闭的、适形的、粘附的聚合物膜，其不刺痛和不燃烧，以及氧气和水蒸气可渗透。体外初步研究表明，这些液体绷带中的某些产生透明的水不溶性膜，其用作人表皮角质形成细胞和人皮肤成纤维细胞生长的支架。本建议的目的是确定哪种新型液体粘性绷带组合物在提供部分厚度伤口愈合的最大加速方面最有效。没有市售的、紧密贴合的液体粘性绷带显示出支持细胞生长作为伤口愈合的手段。这项研究的独特聚合物涂层可能对其在伤口护理敷料中的使用产生重大影响。迈阿密大学皮肤科和皮肤外科系的伤口愈合和感染研究实验室将基于所提供的优选液体粘性绷带制剂，在猪模型上对深部部分厚度伤口进行炎症评估和伤口愈合方案。该猪模型已在许多伤口护理产品中使用并得到验证，包括水胶体、水凝胶、透明膜和封闭敷料。将考虑优化制剂用于II期试验。Rochal Industries，Inc.，RochalIndustries，LLP的姊妹公司先前发明了一种基于双乙酰基的液体粘性绷带，该绷带由3M公司许可并商业化（用于医院和疗养院的3MCavilon无刺屏障膜，和用于OTC的3MNexcare喷雾液体绷带无刺）。虽然商业化的绷带不具有目前提出的绷带的独特性质，但目前的公司非常熟悉通过许可进行商业化的过程。