MEG of Somatosensory & Attentional Processes

体感MEG

• 批准号: 6883892
• 负责人: ANDREW C. PAPANICOLAOU
• 金额: $ 43.93万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883892
• 关键词: attention; behavior test; bioimaging /biomedical imaging; cerebral ischemia /hypoxia; functional ability; human middle age (35-64); human subject; magnetic resonance imaging; magnetoencephalography; neural plasticity; neuropsychological tests; neuropsychology; patient oriented research; psychometrics; rehabilitation; somesthetic sensory cortex; stroke; visual stimulus

The objective of this proposal is to address the question of how changes in cortical activity that follow ischemic insult are related to functional improvement of somatosensory and attentional processes. In order to meet this objective, we will specify the parameters of cerebral reorganization underlying recovery of somatosensory and attentional functions in patients with unilateral ischemic stroke using magnetoencephalography (MEG). We will then determine the correspondence between MEG parameters of reorganization and relevant behavioral measures of recovery of function. In addition, we will outline the relation between stroke lesion variables (volume and location) and MEG-based indices of reorganization, as well as between lesion variables and behavioral measures of functional recovery. An understanding of cortical mechanisms of recovery and reorganization will help determine prognosis and optimal treatment for individuals recovering from somatosensory and attentional deficits following cortical infarction. The study design includes a baseline behavioral and neuropsychological assessment followed by MEG and MRI imaging at 2-3 months and 10-12 months post-stroke. We will obtain spatiotemporal MEG maps of brain activity associated with stimulation of the fingertips of both hands in patients with current or prior hemianesthesia at these two time intervals. A subset of these patients will have undergone constraint-induced therapy (CIT) and will be compared with control participants who have been treated with standard care therapy. We will also obtain spatiotemporal maps of cortical activity associated with selective attention to visual stimuli in patients recovering or recovered from unilateral neglect (with or without hemianesthesia) over the same time interval. Changes in MEG parameters (anatomical location, magnitude, and time course of the event-related magnetic response) will establish the nature and extent of reorganization in relation to behavioral and cognitive recovery. The relations between these parameters and detailed volumetric analyses of structural MRIs obtained at the same time periods will reveal associations between stroke type and cortical reorganization related to recovery.

这项建议的目的是解决这样一个问题，即缺血性损伤后皮质活动的变化如何与躯体感觉和注意过程的功能改善有关。为了达到这一目标，我们将利用脑磁图(MEG)确定单侧缺血性卒中患者躯体感觉和注意功能恢复的脑重组参数。然后，我们将确定重组的脑磁图参数与相关的功能恢复行为指标之间的对应关系。此外，我们将概述卒中病变变量(体积和位置)与基于脑磁图的重组指数之间的关系，以及病变变量与功能恢复的行为指标之间的关系。了解皮层恢复和重组的机制将有助于确定预后和皮质梗塞后躯体感觉和注意缺陷恢复的最佳治疗方案。研究设计包括基线行为和神经心理学评估，然后在中风后2-3个月和10-12个月进行脑磁图和核磁共振成像。我们将在这两个时间间隔获得与刺激双手指尖相关的脑磁图。这些患者中的一部分将接受强制诱导治疗(CIT)，并将其与接受标准护理治疗的对照组参与者进行比较。我们还将获得与选择性注意视觉刺激相关的皮层活动的时空图，这些患者正在从单侧忽视中恢复或康复(有或没有半麻醉)。 在相同的时间间隔内。脑磁图参数的变化(事件相关磁反应的解剖位置、大小和时间进程)将确定与行为和认知恢复有关的重组的性质和程度。这些参数与同一时期获得的结构磁共振成像的详细体积分析之间的关系将揭示中风类型与与恢复相关的皮质重组之间的关联。