Integration of MSI/fMRI Studies of Reading

MSI/fMRI 阅读研究的整合

• 批准号: 6667164
• 负责人: ANDREW C. PAPANICOLAOU
• 金额: $ 32.45万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6667164
• 关键词: adult human (21+); bioimaging /biomedical imaging; cerebrovascular imaging /visualization; clinical research; cognition; functional magnetic resonance imaging; human middle age (35-64); human subject; interdisciplinary collaboration; language; neural information processing; reading

DESCRIPTION (provided by applicant): The primary goals of the proposed study are to (a) develop an interdisciplinary network addressing the integration of two different methodologies for functional neuroimaging, magnetic source imaging (MSI) and functional magnetic resonance imaging (fMRI) in order to (b) evaluate a model of the cerebral mechanisms that support skilled reading. These methods differ in their sensitivity to the spatial and temporal components involved when the brain is activated while performing a cognitive task. By combining the strengths of the University of Texas-Houston MSI laboratory and the resources for fMRI at the Haskins Laboratories/Yale University, both of which have published extensively on the neural mechanisms underlying reading, we will integrate these two functional neuroimaging modalities and develop a more comprehensive model of the cerebral mechanisms underlying skilled reading. This model stipulates that printed word recognition is related to the development of a highly organized cortical system that integrates orthographic, phonological and lexical-semantic features of words. This system involves two posterior circuits in the left hemisphere (LH): a dorsal (temporo-parietal) and a ventral (occipito-temporal) circuit, along with a third circuit (inferior frontal gyms). Each circuit has a different role in reading, varying not only spatially, but also temporally. A series of experiments are proposed involving 30 healthy adults who would receive both MSI and fMRI imaging modalities while performing different reading tasks in order to (a) determine precisely which brain areas are functional components of the neural circuits supporting reading; (b) determine how the three putative neural circuits differ from one another in terms of the types of information processing performed by each. We will systematically modulate demands on different component processes in word recognition to reveal differences in the kinds of information each circuit processes; and (c) determine how the three circuits interact with each other in real time to support by integrating three types of data: spatial extent of regional activation, relative timing of the engagement of different brain areas, and functional connectivity. We also propose cross training in the two technologies and the development of an interdisciplinary network composed of investigators at both institutions. Together these efforts will expand the interpretability of imaging data by direct comparison and integration of the techniques and lead to a more elaborated theory of the cerebral mechanisms underlying reading.

描述（由申请人提供）： 拟议研究的主要目标是（a）开发一个跨学科网络，解决功能性神经成像，磁源成像（MSI）和功能性磁共振成像（fMRI）的两种不同的方法的整合，以便（B）评估支持熟练阅读的大脑机制的模型。这些方法对执行认知任务时大脑被激活时所涉及的空间和时间分量的敏感度不同。通过结合德克萨斯大学休斯顿MSI实验室的优势和哈斯金斯实验室/耶鲁大学的功能磁共振成像资源，这两个实验室都发表了大量关于阅读的神经机制的文章，我们将整合这两种功能性神经成像模式，并开发一个更全面的熟练阅读的大脑机制模型。该模型认为，印刷字识别与高度组织化的皮层系统的发展有关，该系统整合了字的拼写、语音和词汇语义特征。该系统涉及左半球（LH）的两个后部回路：背侧（颞顶）和腹侧（枕颞）回路，沿着第三个回路（额下回）。每个电路在阅读中具有不同的作用，不仅在空间上变化，而且在时间上变化。一系列的实验，提出涉及30名健康的成年人谁将接受MSI和功能磁共振成像模式，同时执行不同的阅读任务，以（a）准确地确定哪些脑区的功能组件的神经回路支持阅读;（B）确定如何三个假定的神经回路不同，从彼此的信息处理的类型进行。我们将系统地调节对单词识别中不同组成过程的需求，以揭示每个回路处理的信息种类的差异;（c）确定三个回路如何在真实的时间内相互作用，以通过整合三种类型的数据来支持：区域激活的空间范围，不同大脑区域参与的相对时间，以及功能连接。我们还建议在这两种技术的交叉培训，并在这两个机构的调查人员组成的跨学科网络的发展。这些努力将通过直接比较和整合技术来扩大成像数据的可解释性，并导致阅读的大脑机制的更详细的理论。