Integration of MSI/fMRI Studies of Reading

MSI/fMRI 阅读研究的整合

• 批准号: 6667164
• 负责人: ANDREW C. PAPANICOLAOU
• 金额: $ 32.45万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6667164
• 关键词: adult human (21+); bioimaging /biomedical imaging; cerebrovascular imaging /visualization; clinical research; cognition; functional magnetic resonance imaging; human middle age (35-64); human subject; interdisciplinary collaboration; language; neural information processing; reading

DESCRIPTION (provided by applicant): The primary goals of the proposed study are to (a) develop an interdisciplinary network addressing the integration of two different methodologies for functional neuroimaging, magnetic source imaging (MSI) and functional magnetic resonance imaging (fMRI) in order to (b) evaluate a model of the cerebral mechanisms that support skilled reading. These methods differ in their sensitivity to the spatial and temporal components involved when the brain is activated while performing a cognitive task. By combining the strengths of the University of Texas-Houston MSI laboratory and the resources for fMRI at the Haskins Laboratories/Yale University, both of which have published extensively on the neural mechanisms underlying reading, we will integrate these two functional neuroimaging modalities and develop a more comprehensive model of the cerebral mechanisms underlying skilled reading. This model stipulates that printed word recognition is related to the development of a highly organized cortical system that integrates orthographic, phonological and lexical-semantic features of words. This system involves two posterior circuits in the left hemisphere (LH): a dorsal (temporo-parietal) and a ventral (occipito-temporal) circuit, along with a third circuit (inferior frontal gyms). Each circuit has a different role in reading, varying not only spatially, but also temporally. A series of experiments are proposed involving 30 healthy adults who would receive both MSI and fMRI imaging modalities while performing different reading tasks in order to (a) determine precisely which brain areas are functional components of the neural circuits supporting reading; (b) determine how the three putative neural circuits differ from one another in terms of the types of information processing performed by each. We will systematically modulate demands on different component processes in word recognition to reveal differences in the kinds of information each circuit processes; and (c) determine how the three circuits interact with each other in real time to support by integrating three types of data: spatial extent of regional activation, relative timing of the engagement of different brain areas, and functional connectivity. We also propose cross training in the two technologies and the development of an interdisciplinary network composed of investigators at both institutions. Together these efforts will expand the interpretability of imaging data by direct comparison and integration of the techniques and lead to a more elaborated theory of the cerebral mechanisms underlying reading.

描述（由申请人提供）：拟议的研究的主要目标是（a）建立一个跨学科网络，以解决两种不同方法的功能神经成像，磁源成像（MSI）和功能磁共振成像（FMRI）的整合，以评估（b）评估脑机制的模型，以支持脑机制。这些方法在执行认知任务时激活大脑时对涉及的空间和时间成分的敏感性有所不同。通过结合德克萨斯大学MSI实验室的优势和Haskins Laboratories/Yale University的fMRI资源，它们都大量发表了有关阅读的神经机制的大量发表，我们将整合这两种功能性神经影像学模式，并在脑化机制下更加全面地读取了脑介绍熟练的熟练型熟练的脑化。该模型规定，印刷单词识别与高度有组织的皮质系统的开发有关，该系统整合了单词的拼字，语音和词汇 - 语义特征。该系统涉及左半球（LH）中的两个后路：背侧（颞叶 - 长方形）和一个腹侧（枕骨 - 速率）电路，以及第三个电路（下额健身房）。每个电路在阅读中具有不同的作用，不仅在空间上，而且在时间上也有所不同。提出了一系列实验，涉及30名健康成年人，他们将同时接受MSI和fMRI成像方式，同时执行不同的阅读任务，以确切确切确定哪些大脑区域是支持阅读的神经回路的功能组成部分； （b）确定三个假定的神经回路在每个人执行的信息处理的类型方面彼此之间有何不同。我们将系统地调节对单词识别中不同组件过程的需求，以揭示每个电路过程中各种信息的差异； （c）确定三个电路如何实时相互交互，以通过整合三种类型的数据来支持：区域激活的空间范围，不同大脑区域的参与度的相对时机以及功能连接性。我们还建议在这两种技术中进行交叉培训，并提出由两个机构研究人员组成的跨学科网络的发展。这些努力将通过直接比较和整合技术扩展成像数据的解释性，并导致对阅读脑的脑机制的更精确的理论。