Identification and development of Plasmodium falciparum complement-binding proteins as vaccine candidates

恶性疟原虫补体结合蛋白候选疫苗的鉴定和开发

• 批准号: nhmrc : 1053924
• 负责人: Dr Greta Weiss
• 金额: $ 21.02万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-development-plasmodium-vaccine-candidates/112357
• 关键词: Identification; development; Plasmodium; falciparum; complement

Parasites causing malaria live inside red blood cells. Some human proteins act in a chain reaction to destroy infected cells. Although these proteins recognise parasite-infected cells and the chain reaction starts, the infected cells are not destroyed due to parasite proteins which inhibit the human proteins. A vaccine could induce antibodies which block the parasite proteins inhibiting the human proteins so the immune system can function normally and kill infected cells, thus stopping malaria.

引起疟疾的寄生虫生活在红细胞内。一些人类蛋白质通过连锁反应破坏被感染的细胞。尽管这些蛋白质能识别被寄生虫感染的细胞并开始链式反应，但受感染的细胞不会因为寄生虫蛋白质抑制人类蛋白质而被破坏。一种疫苗可以诱导阻断寄生虫蛋白质的抗体，抑制人类蛋白质，这样免疫系统就可以正常运作，杀死受感染的细胞，从而阻止疟疾。