GNRH WEBSITE (U-54 SUPPLEMENT)

GNRH 网站（U-54 补充件）

• 批准号: 7561977
• 负责人: CHRISTOPHER J DUBAY
• 金额: $ 1.47万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7561977
• 关键词: Clinical Informatics; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Doctor of Philosophy; Elements; Funding; Goals; Gonadotropin-Releasing Hormone Receptor; Grant; Hypothalamic structure; Informatics; Institution; Internet; Link; Literature; Medical Informatics; Modeling; Neurons; Pathway interactions; Research; Research Personnel; Resources; Signal Pathway; Site; Source; Students; System; Systems Biology; Technology; United States National Institutes of Health; Work; biomedical informatics; clinical epidemiology; design; programs; web based interface

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The GnRH Website project is making good progress in accomplishing its goal of delivering a web based interface to systems biology models of the GnRH pathway and related clinical and research resources. We have assembled a team of bioinformaticians (two Masters, and one PhD student from the OHSU Department of Medical Informatics & Clinical Epidemiology Biomedical Informatics program) being led by Dr. Christopher Dubay, who are all working on various aspects of the project. We have deployed an internal version of the web site, and are iteratively designing the functionality with ONPRC researchers; most actively Dr. Sergio Ojeda. The site currently contains an interactive signaling pathway for the GnRH receptor system with inter-element links annotated by literature references supporting the depicted interactions. The model will be extended to include the control of hypothalamic GnRH secretion and other mechanisms regulating GnRH neuronal activity. It will be also made more interactive by allowing users to make versions of models with user added annotations. These versions, including versions for various species, will be comparable in a way that helps visually highlight differences between versions (using informatics technologies such as Adobe SVG: http://www.adobe.com/svg/).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 GnRH网站项目在实现其目标方面取得了良好的进展，该目标是为GnRH途径的系统生物学模型和相关临床和研究资源提供基于网络的界面。我们已经组建了一个生物信息学家团队（两名硕士和一名来自OHSU医学信息学与临床流行病学生物医学信息学计划部门的博士生），由Christopher Dubay博士领导，他们都致力于该项目的各个方面。 我们已经部署了网站的内部版本，并正在与ONPRC研究人员迭代设计功能;最活跃的是Sergio Ojeda博士。该网站目前包含GnRH受体系统的相互作用信号通路，元件间的链接由支持所描述的相互作用的参考文献注释。该模型将扩展到包括下丘脑GnRH分泌的控制和其他调节GnRH神经元活性的机制。它还将通过允许用户使用用户添加的注释来制作模型版本，从而更具交互性。这些版本，包括各种物种的版本，将以有助于在视觉上突出不同版本之间差异的方式进行比较（使用信息技术，如Adobe SVG：http：//www.adobe.com/svg/）。