COLONY DEMOGRAPHICS & INFORMATICS (CDI) UNIT [FORMERLY GRIP]

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 ONPRC灵长类遗传学计划的群体人口统计和信息学(CDI)单元的目的是指导ONPRC群体基因分型计划，确保有效的亲子关系和谱系分配，并监测群体多样性指标(创始人代表、平均亲属关系值、遗传漂移)。这些分析为猕猴繁殖群体的健康管理提供了信息和支持，提供了准确的信息，以实现更高的繁殖成功率和群体中的遗传平衡。这些努力还产生了广泛的群体谱系，这是ONPRC基因研究调查和动物模型开发的关键基础。 CDI支持生物医学研究和群体管理数据的分析，包括基因类型和表型，以及带有本地注释的基因组、蛋白质组和基因表达数据，包括动物亚群数据(例如，恒河猴数据的印度和中国起源)。CDI对所有ONPRC猴子进行亲子鉴定和DNA银行。我们通过我们基于网络的GRIPdb(灵长类动物遗传关系和信息数据库)向研究人员和动物资源部(DAR)提供这些资源，我们与他们密切合作，提供关于遗传信息群体状况和管理的报告。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Colony Demographics & Informatics (CDI) Unit of the ONPRC Primate Genetics Program is to direct the ONPRC colony genotyping program, ensuring validated parentage and pedigree assignments and the monitoring of population diversity metrics (founder representation, mean kinship values, genetic drift). These analyses inform and support the healthy management of the macaque breeding colonies, by providing accurate information to achieve increased reproductive success and genetic balance in the colony. These efforts also generate the extensive colony pedigree that is the critical foundation for both genetic research investigations and animal model development at the ONPRC. The CDI supports the analysis of biomedical research and colony management data including genotypes and phenotypes, as well as genomic, proteomic, and gene expression data with local annotations including sub-population data on animals (e.g., Indian vs. Chinese origin for rhesus data). The CDI performs parentage genotyping and DNA banking on all ONPRC monkeys. We deliver these resources via our Web based GRIPdb (Genetic Relations and Information of Primates database) to researchers and the Department of Animal Resources (DAR), with whom we work very closely to provide reports for genetically informed colony status and management.