COLONY DEMOGRAPHICS & INFORMATICS (CDI) UNIT [FORMERLY GRIP]

殖民地人口统计

• 批准号: 7958430
• 负责人: CHRISTOPHER J DUBAY
• 金额: $ 5.02万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-04 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958430
• 关键词: Animals; Biomedical Research; Breeding; Chinese People; Computer Retrieval of Information on Scientific Projects Database; DNA Library; Data; Databases; Ensure; Equilibrium; Foundations; Funding; Gene Expression; Genetic; Genetic Drift; Genetic Programming; Genetic Research; Genomics; Genotype; Grant; Informatics; Institution; Investigation; Macaca; Macaca mulatta; Metric; Monitor; Monkeys; Online Systems; Phenotype; Population; Primates; Proteomics; Reporting; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Work; animal model development; animal resource; data management; demographics; genetic pedigree; grasp; programs; reproductive success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Colony Demographics & Informatics (CDI) Unit of the ONPRC Primate Genetics Program is to direct the ONPRC colony genotyping program, ensuring validated parentage and pedigree assignments and the monitoring of population diversity metrics (founder representation, mean kinship values, genetic drift). These analyses inform and support the healthy management of the macaque breeding colonies, by providing accurate information to achieve increased reproductive success and genetic balance in the colony. These efforts also generate the extensive colony pedigree that is the critical foundation for both genetic research investigations and animal model development at the ONPRC. The CDI supports the analysis of biomedical research and colony management data including genotypes and phenotypes, as well as genomic, proteomic, and gene expression data with local annotations including sub-population data on animals (e.g., Indian vs. Chinese origin for rhesus data). The CDI performs parentage genotyping and DNA banking on all ONPRC monkeys. We deliver these resources via our Web based GRIPdb (Genetic Relations and Information of Primates database) to researchers and the Department of Animal Resources (DAR), with whom we work very closely to provide reports for genetically informed colony status and management.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 ONPRC灵长类遗传学计划的殖民地统计学和信息学（CDI）部门的目的是指导ONPRC族群基因分型计划，确保有效的亲子关系和谱系分配，并监测种群多样性指标（创始人代表性、平均亲属关系值、遗传漂变）。这些分析通过提供准确的信息，为猕猴繁殖群的健康管理提供信息和支持，以提高殖民地的繁殖成功率和遗传平衡。这些努力还产生了广泛的群体谱系，这是ONPRC遗传研究调查和动物模型开发的关键基础。 CDI支持生物医学研究和群体管理数据的分析，包括基因型和表型，以及基因组学、蛋白质组学和基因表达数据，并带有本地注释，包括动物的亚群数据（例如，恒河猴数据的印度与中国来源）。CDI对所有ONPRC猴进行亲子基因分型和DNA库。我们通过基于Web的GRIPdb（灵长类动物遗传关系和信息数据库）向研究人员和动物资源部（DAR）提供这些资源，我们与他们密切合作，为遗传信息的群体状态和管理提供报告。