DO ORAL CONTRACEPTIVES CAUSE WEIGHT GAIN?

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项资助旨在探索口服避孕药对成年期体重控制的影响。 许多妇女停止服用口服避孕药，因为她们担心会有副作用，体重增加。但是，这种未能持续服用口服避孕药导致意外怀孕率增加。令人惊讶的是，在动物（小鼠、大鼠、猫、狗、猴）中的研究表明，对卵巢切除动物施用雌激素和孕酮通常导致体重减轻，而不是体重增加。这项资助的总体目标是记录卵巢完整的灵长类动物长期口服避孕药一年后体重的变化。 我们假设，服用口服避孕药一年的猴子没有体重增加，但实际上可能会经历轻微的体重减轻;这一发现将怀疑口服避孕药导致体重增加的副作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This grant explores the effect of oral contraceptives on body weight control in adulthood. Many women stop taking oral contraceptives because they are concerned about a perceived side effect, weight gain. But this failure to consistently take oral contraceptives leads to increased rates of unintended pregnancy. Surprisingly, studies in animals (mice, rats, cats, dogs, monkeys) have shown that estrogen and progesterone administration to ovariectomized animals generally leads to weight loss, rather than weight gain. The overall goal of this grant is to document changes in body weight when ovary-intact primates are chronically given oral contraceptives for a one-year period of time. We hypothesize that monkeys taking oral contraceptives for a year with not experience weight gain, but may in fact experience a mild weight loss; a finding which would discredit the perceived side effect of oral contraceptives in causing weight gain.