DO ORAL CONTRACEPTIVES CAUSE WEIGHT GAIN?

口服避孕药会导致体重增加吗？

• 批准号: 8173240
• 负责人: ALISON B EDELMAN
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173240
• 关键词: Adult; Adverse effects; Adverse event; Affect; Animals; Body Weight; Body Weight decreased; Body fat; Canis familiaris; Computer Retrieval of Information on Scientific Projects Database; Eating; Estrogens; Failure; Felis catus; Female; Funding; Goals; Grant; Hour; Institution; Metabolic; Monkeys; Mus; Obesity; Oral Contraceptives; Ovary; Primates; Progesterone; Protocols documentation; Rattus; Research; Research Personnel; Resources; Source; Time; United States National Institutes of Health; Weight; Weight Gain; Weight maintenance regimen; Woman; base; experience; muscle form; pill; unintended pregnancy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This grant explores the effect of oral contraceptives on body weight control in adulthood. Many women stop taking oral contraceptives because they are concerned about a perceived side effect, weight gain. But this failure to consistently take oral contraceptives leads to increased rates of unintended pregnancy. Surprisingly, studies in animals (mice, rats, cats, dogs, monkeys) have shown that estrogen and progesterone administration to ovariectomized animals generally leads to weight loss, rather than weight gain. The overall goal of this grant is to document changes in body weight when ovary-intact primates are chronically given oral contraceptives(OC) for a one-year period of time. We hypothesized that monkeys taking oral contraceptives for a yearmay in fact experience a mild weight loss; a finding which would discredit the perceived side effect of oral contraceptives in causing weight gain. All monkeys completed the study protocol with no adverse events. A significant increase in metabolic rate, a decrease in body weight, and a decrease in % body fat with pill use was found as compared to baseline. When analyzing the groups separately (obese versus normal), the obese group was responsible for the significant changes seen for the entire group.. No changes were seen in food intake, activity level, or % lean muscle mass with OC use for the entire group and for either BMI-based group. Overall, OC use appears to increase 24 hour metabolic rate in female monkeys, which in turn appears to differentially affect weight and % body fat depending on baseline weight.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该赠款探讨了口服避孕药对成年后体重控制的影响。 许多妇女停止服用口服避孕药，因为她们担心感知的副作用，体重增加。但是这种未能持续服用口服避孕药的导致意外怀孕率提高。令人惊讶的是，对动物（小鼠，大鼠，猫，狗，猴子）进行的研究表明，雌激素和孕激素对卵巢切除动物的施用通常会导致体重减轻，而不是体重增加。这笔赠款的总体目标是记录卵巢直觉灵长类动物在一年的时间内长期服用口服避孕药（OC）时体重变化。 我们假设猴子服用口服避孕药，实际上是一岁的可能会轻微体重减轻。这一发现会抹黑口服避孕药在导致体重增加方面的副作用。所有猴子都完成了研究方案，没有不良事件。与基线相比，发现代谢率的显着增加，体重减少以及使用药丸的体脂降低。 在分别分析组（肥胖与正常）时，肥胖组负责整个组的重大变化。在食物摄入，活动水平，或瘦肌肉质量百分比中，整个组和基于BMI的组都没有变化。 总体而言，OC的使用似乎增加了雌性猴子的24小时代谢率，而雌性猴子的使用似乎会差异地影响体重和％脂肪，具体取决于基线体重。