A NOVEL MECHANISM OF ANDROGEN RECEPTOR ACTION

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的目标是表征一种新的HER-2变体（herstatin）对前列腺癌中IGF-IR作用的影响。该项目的订正目标是： 1. 表征herstatin在前列腺癌细胞中的作用。 2. 评估前列腺癌细胞系和临床样本中herstatin的表达。 3. 研究herstatin表达的调控。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is the characterization of the effects of a novel HER-2 variant (herstatin) on IGF-IR action in prostate cancer. The revised aims of this project are to: 1. Characterize the effects of herstatin in prostate cancer cells. 2. Evaluate expression of herstatin in prostate cancer cell lines and clinical samples. 3. Investigate regulation of herstatin expression.