RHESUS HHV8 HOMOLOGUE IN AIDS-RELATED MALIGNANCIES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我的实验室正在利用猴免疫缺陷病毒(SIV)/恒河猴横纹病毒(RRV)/恒河猴(RM)动物模型来阐明RRV如何能够重现人类疱疹病毒8型(HHV8)能够在艾滋病患者中诱导的许多淋巴增殖性疾病(LPD)。这些疾病包括多中心性Castleman病(MCD)和非霍奇金淋巴瘤(NHL)。在规定的资助期内，我的实验室致力于进一步发展这一动物模型，并阐明哪些细胞类型的RRV能够在体内感染，以及哪些病毒基因产物可能在维持感染和疾病进展中发挥作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. My laboratory is utilizing the simian immunodeficiency virus (SIV)/rhesus rhadinovirus (RRV)/rhesus macaque (RM) animal model to elucidate how RRV is able to recapitulate many of the lymphoproliferative disorders (LPD) that human herpesvirus 8 (HHV8) is capable of inducing in AIDS patients. These include multicentric Castleman's disease (MCD) and non-Hodgkin's lymphoma (NHL). During the defined funding period, my laboratory has focused on further developing this animal model and elucidating which cell types RRV is capable of infecting in vivo, and which viral gene products may play a role in the maintenance of infection and disease progression.