EXPANDING VIROLOGY IN THE NON-HUMAN PRIMATE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 非人灵长类动物（NHP）是人类的近亲，因此是生物医学研究的宝贵资源。在所有的NHP中，黑猩猩是人类的近亲，但使用这种高度濒危的物种进行实验研究会引起道德约束。或者，旧世界猕猴，如恒河猴（Macaca mulatta）（RM），代表合适的动物模型，因为RM与人类具有密切的遗传、生理和免疫相似性。RM的效用是有据可查的研究方面的人类生殖生物学和获得性免疫缺陷综合征（艾滋病）的发病机制，但较少开发的其他疾病表现，影响人类健康，如其他病毒和遗传为基础的疾病条件。该开发提案的长期目标是进一步开发RM模型，用于阐明病毒性疾病状态和评价基于病毒的治疗方法，以应用于人类健康。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Non-human primates (NHP) are close relatives to humans and because of this represent a valuable resource for biomedical research. Of all the NHP the chimpanzee is the closest relative of humans, but the usage of this highly endangered species for experimental research raises ethical constraints. Alternatively, Old World macaques, such as rhesus macaques (Macaca mulatta) (RM), represent suitable animal models as RM share close genetic, physiological and immunological similarities with humans. The utility of RM is well documented for studying aspects of human reproductive biology and acquired immunodeficiency syndrome (AIDS) pathogenesis, but is less developed for other disease manifestations that affect human health, such as other viral- and genetic-based disease conditions. The long-term goals of this developmental proposal are to further develop the RM model for elucidation of viral disease states and the evaluation of viral-based therapies for application to human health.