Oral transmission of KSHV using rhesus macaque rhadinovirus model

使用恒河猴鼻病毒模型经口传播 KSHV

基本信息

  • 批准号:
    10686217
  • 负责人:
  • 金额:
    $ 79.11万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-01 至 2027-08-31
  • 项目状态:
    未结题

项目摘要

SUMMARY The long-term goals and objectives of this proposal is to investigate host and virological factors associated with oral transmission of Kaposi’s sarcoma-associated herpesvirus (KSHV) utilizing the closely related rhesus macaque rhadinovirus (RRV) infection of rhesus macaques (RM) model that parallels KSHV infection and pathogenicity in humans. Like KSHV, RRV is a gamma-2 herpesvirus that is closely related to KSHV at the genomic level, possessing essentially collinear genome organization. Pathologically, RRV closely resembles KSHV, as we have shown that intravenous (iv) inoculation of RRV can induce KSHV-like disease manifestations in RM co-infected with simian immunodeficiency virus (SIV). Similarly, RM are infected with RRV early in life, within the first 2 years, implying RRV infection mimics KSHV infection in children living in sub-Saharan Africa, where KSHV is acquired early in life. Here, we will determine whether RRV can cross the oral mucosa to establish infection, and identify the in vivo conditions necessary. These first of kind studies for RRV will be performed in parallel with in vitro studies to interrogate viral glycoprotein receptor(s) density and cell types expressing the receptor(s) in different regions of the oral cavity, as a means to define the mechanism for transmission. Lastly, as we have created an infectious and pathogenic bacterial artificial chromosome (BAC) clone of wild type RRV (WT-RRVBAC) that provides a molecular genetic system to interrogate viral factors that are necessary for infection, we will undertake a molecular approach to interrogate viral encoded factors that facilitate KSHV infection across the oral mucosa. Specifically, we hypothesize that RRV envelope glycoproteins gB, gH, gL, gM and potentially gR8.1 are necessary for binding to receptors on susceptible cells and that KSHV glycoproteins gB, gH, gL, gM and gK8.1 can functionally substitute for RRV glycoprotein homologues. Hence, establishing this chimeric virus system will enable researchers and vaccinologists, the ability to target the viral glycoproteins for vaccine approaches in a nonhuman primate (NHP) model.
总结

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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SCOTT W WONG其他文献

SCOTT W WONG的其他文献

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{{ truncateString('SCOTT W WONG', 18)}}的其他基金

Oral transmission of KSHV using rhesus macaque rhadinovirus model
使用恒河猴鼻病毒模型经口传播 KSHV
  • 批准号:
    10541061
  • 财政年份:
    2022
  • 资助金额:
    $ 79.11万
  • 项目类别:
Induction of robust T cell response to RRV-LANA
诱导 T 细胞对 RRV-LANA 产生强烈反应
  • 批准号:
    8660772
  • 财政年份:
    2013
  • 资助金额:
    $ 79.11万
  • 项目类别:
Induction of robust T cell response to RRV-LANA
诱导 T 细胞对 RRV-LANA 产生强烈反应
  • 批准号:
    8774212
  • 财政年份:
    2013
  • 资助金额:
    $ 79.11万
  • 项目类别:
ANTI-VIRAL IL-6 APPROACH TO MITIGATE KSHV-RELATED DISEASE
减轻 KSHV 相关疾病的抗病毒 IL-6 方法
  • 批准号:
    8357749
  • 财政年份:
    2011
  • 资助金额:
    $ 79.11万
  • 项目类别:
RHESUS HHV8 HOMOLOGUE IN AIDS-RELATED MALIGNANCIES
艾滋病相关恶性肿瘤中的恒河猴 HHV8 同源物
  • 批准号:
    8357730
  • 财政年份:
    2011
  • 资助金额:
    $ 79.11万
  • 项目类别:
ANTI-VIRAL IL-6 APPROACH TO MITIGATE KSHV-RELATED DISEASE
减轻 KSHV 相关疾病的抗病毒 IL-6 方法
  • 批准号:
    8173201
  • 财政年份:
    2010
  • 资助金额:
    $ 79.11万
  • 项目类别:
RHESUS HHV8 HOMOLOGUE IN AIDS-RELATED MALIGNANCIES
艾滋病相关恶性肿瘤中的恒河猴 HHV8 同源物
  • 批准号:
    8173176
  • 财政年份:
    2010
  • 资助金额:
    $ 79.11万
  • 项目类别:
GAMMA-2 HERPESVIRUS-ASSOCIATED JAPANESE MACAQUE ENCEPHALOMYELITIS
GAMMA-2 疱疹病毒相关日本猕猴脑脊髓炎
  • 批准号:
    8173262
  • 财政年份:
    2010
  • 资助金额:
    $ 79.11万
  • 项目类别:
IDENTIFYING TARGETS FOR THERAPEUTIC INTERVENTIONS USING PROTEOMIC TECHNOLOGY
使用蛋白质组学技术确定治疗干预目标
  • 批准号:
    8173198
  • 财政年份:
    2010
  • 资助金额:
    $ 79.11万
  • 项目类别:
TARGETING CELLULAR PROCESSES TO INHIBIT MONKEYPOX VIRUS INFECTION IN VIVO
靶向细胞过程抑制体内猴痘病毒感染
  • 批准号:
    8173217
  • 财政年份:
    2010
  • 资助金额:
    $ 79.11万
  • 项目类别:

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