DEVELOPMENT OF A NONHUMAN PRIMATE MODEL FOR VARICELLA AND HERPES ZOSTER

水痘和带状疱疹非人灵长类动物模型的开发

• 批准号: 7958464
• 负责人: Ilhem Messaoudi
• 金额: $ 6.04万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-04 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958464
• 关键词: Animal Model; Chickenpox; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Funding; Grant; Herpes zoster disease; Herpesvirus Type 3; Immune response; Institution; Macaca mulatta; Modeling; Pain; Primates; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Virus; nonhuman primate; reactivation from latency; virus pathogenesis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The reactivation of latent varicella zoster virus (VZV) results in the painful and debilitating disease known as shingles. Our understanding of the immune response to VZV remains incomplete because studies on VZV pathogenesis, latency and reactivation are severely hampered by the lack of an appropriate animal model. We proposed to develop a new animal model whereby rhesus macaques are infected with the closely related simian varicella virus (SVV).

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