EFFECT OF VISCERAL FAT ON INSULIN SENSITIVITY

内脏脂肪对胰岛素敏感性的影响

• 批准号: 7957934
• 负责人: RAUL A BASTARRACHEA
• 金额: $ 2.8万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-06 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957934
• 关键词: Adipose tissue; Computer Retrieval of Information on Scientific Projects Database; Excision; Fatty acid glycerol esters; Funding; Grant; Hypertension; Inflammation; Institution; Insulin; Intra-abdominal; Liver; Metabolic; Metabolic Diseases; Muscle; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Omentum; Overweight; Papio; Primates; Procedures; Research; Research Personnel; Resources; Risk; Risk Factors; Source; United States National Institutes of Health; Visceral; abdominal fat; improved; insulin sensitivity; male

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Excessive intra-abdominal (visceral) fat is associated with an increased risk of metabolic disease, including type 2 diabetes, dylipidemia, and hypertension. However, it is not known whether visceral fat is actually responsible for, or is simply associated with, these metabolic abnormalities. This proposal will evaluate the metabolic effects of decreasing intra-abdominal fat mass by resection of the omentum in overweight male baboons and will determine the mechanisms involved. It is expected that this procedure will result in improved muscle/adipose tissue and liver sensitivity to insulin (risk factors of type 2 diabetes), reduced levels of inflammation in the liver and muscle. Thus the information acquired will aid clinicians and researchers in focusing their efforts on reducing the societal burden of obesity-related metabolic disease.

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