EFFECT OF VISCERAL FAT ON INSULIN SENSITIVITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 腹内(内脏)脂肪过多会增加代谢性疾病的风险，包括2型糖尿病、血脂异常和高血压。然而，尚不清楚内脏脂肪是否是这些代谢异常的真正原因，或者只是与之有关。这项建议将评估通过切除大网膜来减少超重雄性狒狒腹内脂肪质量的代谢效果，并将确定相关的机制。预计这一手术将改善肌肉/脂肪组织和肝脏对胰岛素(2型糖尿病的危险因素)的敏感性，降低肝脏和肌肉的炎症水平。因此，获得的信息将有助于临床医生和研究人员将他们的努力集中在减少肥胖相关代谢性疾病的社会负担上。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Excessive intra-abdominal (visceral) fat is associated with an increased risk of metabolic disease, including type 2 diabetes, dylipidemia, and hypertension. However, it is not known whether visceral fat is actually responsible for, or is simply associated with, these metabolic abnormalities. This proposal will evaluate the metabolic effects of decreasing intra-abdominal fat mass by resection of the omentum in overweight male baboons and will determine the mechanisms involved. It is expected that this procedure will result in improved muscle/adipose tissue and liver sensitivity to insulin (risk factors of type 2 diabetes), reduced levels of inflammation in the liver and muscle. Thus the information acquired will aid clinicians and researchers in focusing their efforts on reducing the societal burden of obesity-related metabolic disease.