EFFECT OF VISCERAL FAT ON INSULIN SENSITIVITY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 过多的腹内（内脏）脂肪与代谢性疾病的风险增加有关，包括2型糖尿病，糖尿病和高血压。然而，目前尚不清楚内脏脂肪是否真的是这些代谢异常的原因，或者只是与这些代谢异常有关。该提案将评估通过切除超重雄性狒狒的网膜来减少腹内脂肪量的代谢效应，并将确定所涉及的机制。预计该手术将改善肌肉/脂肪组织和肝脏对胰岛素（2型糖尿病的风险因素）的敏感性，降低肝脏和肌肉中的炎症水平。因此，获得的信息将有助于临床医生和研究人员集中精力减少肥胖相关代谢疾病的社会负担。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Excessive intra-abdominal (visceral) fat is associated with an increased risk of metabolic disease, including type 2 diabetes, dylipidemia, and hypertension. However, it is not known whether visceral fat is actually responsible for, or is simply associated with, these metabolic abnormalities. This proposal will evaluate the metabolic effects of decreasing intra-abdominal fat mass by resection of the omentum in overweight male baboons and will determine the mechanisms involved. It is expected that this procedure will result in improved muscle/adipose tissue and liver sensitivity to insulin (risk factors of type 2 diabetes), reduced levels of inflammation in the liver and muscle. Thus the information acquired will aid clinicians and researchers in focusing their efforts on reducing the societal burden of obesity-related metabolic disease.