PATHOPHYSIOLOGY OF ATM & P53

ATM 的病理生理学

• 批准号: 7720212
• 负责人: Da-Qing Yang
• 金额: $ 2.87万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720212
• 关键词: Animals; Ataxia-Telangiectasia-Mutated protein kinase; Cell Cycle; Collaborations; Computer Retrieval of Information on Scientific Projects Database; DNA Damage; DNA Repair; Functional disorder; Funding; Goals; Grant; Growth Factor; Institution; Insulin Resistance; Nerve Degeneration; Physiological Processes; Plant Extracts; Process; Protein p53; Proteins; Research; Research Personnel; Resources; Signal Transduction; Source; Stress; TP53 gene; Teton Sioux Indian; Translation Initiation; Translations; United States National Institutes of Health; Yang; ataxia telangiectasia mutated protein; cell type; college; cytotoxic; diabetic rat; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Yang studies signal transduction of growth factors and the mechanism of protein translation initiation. His research focuses on two important proteins, ATM and p53, which are critical for multiple physiological processes such as cell cycle progress, DNA damage repair, neuronal degeneration, and insulin resistance. His goal is to understand how ATM kinase functions in various types of cells in response to growth factors and cytotoxic stresses. He also examines how translation of p53 tumor suppressor is regulated in response to DNA damage signals Dr. Yang will be carrying out a collaborative study with Dr. Sandoval from Oglala Lakota College on the effects of the plant extract on diabetic rats. The purchase of animals and supplies for this collaboration is in process.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 博士杨博士研究生长因子的信号转导和蛋白质翻译起始的机制。他的研究主要集中在两个重要的蛋白质，ATM和p53，这是关键的多个生理过程，如细胞周期的进展，DNA损伤修复，神经元变性和胰岛素抵抗。他的目标是了解ATM激酶如何在各种类型的细胞中响应生长因子和细胞毒性应激而发挥作用。他还研究了p53肿瘤抑制因子的翻译是如何响应DNA损伤信号进行调节的。杨博士将与奥格拉拉拉科塔学院的桑多瓦尔博士合作研究植物提取物对糖尿病大鼠的影响。 为这项合作购买动物和用品的工作正在进行中。