VITAMIN E,OVARIAN CANCER AND FERTILITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个子项目的主要目标是：阐明排卵在表面上皮源性卵巢癌病因学中的预期作用(绵羊模型)，目的是设计预防措施；并通过克服耐药性和非特异性毒性(人SKOV-3和OVCAR-3细胞系；裸鼠异种移植模型)来改善治疗反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objectives of this subproject are to: elucidate the prospective role of ovulation in the etiology of ovarian cancer of surface epithelial origin (sheep model) - with the goal of devising preventive measures; and improve treatment responses by overcoming drug resistance and nonspecific toxicities (human SKOV-3 and OVCAR-3 cell lines; athymic mouse xenograft model).