OVARIAN CANCER: PREVENTION AND TREATMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该子项目的目的是：阐明排卵在表面上皮来源的卵巢癌病因学中的前瞻性作用，目的是制定预防措施（绵羊模型）;通过克服耐药性和非特异性毒性（人SKOV-3和OVCAR-3细胞系;无胸腺小鼠异种移植模型）来改善治疗反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives of this subproject are to: elucidate the prospective role of ovulation in the etiology of ovarian cancer of surface epithelial origin with the goal of devising preventive measures (sheep model); and improve treatment responses by overcoming drug resistance and nonspecific toxicities (human SKOV-3 and OVCAR-3 cell lines; athymic mouse xenograft model).