VITAMIN E,OVARIAN CANCER AND FERTILITY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 卵巢上皮癌是一种与排卵有关的疾病。看来，在卵泡破裂的机制期间产生的遗传毒性/致突变活性氧破坏了在排卵损伤中存活的卵巢表面上皮细胞的DNA;因此，未修复或未致力于凋亡的细胞（由于有缺陷的肿瘤抑制机制）是潜在的问题。由于卵巢癌转移性疾病患者的预后很差，早期发现已被证明是难以捉摸的，因此必须探索前瞻性的化学预防方法。该子项目的主要目的是：1）确定上皮性卵巢癌病因学中的前瞻性致病机制（排卵因素）-旨在制定预防措施; 2）通过克服耐药性来改善治疗反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Epithelial ovarian cancer is an ovulation-related disease. It appears that genotoxic/mutagenic reactive oxygen species generated during the mechanics of follicular rupture damage the DNA of ovarian surface epithelial cells that survive the insult of ovulation; a cell that is not repaired or does not become committed to apoptosis (because of a defective tumor suppressor mechanism) is hence potentially problematic. Since the prognosis for ovarian cancer patients with metastatic disease is so poor, and early detection has proven elusive, it is imperative that prospective methods of chemoprevention be explored. The primary objectives of this subproject are to: 1) identify prospective causative mechanisms (ovulatory factor) in the etiology of epithelial ovarian cancer - with the intention of devising prophylactic measures; and 2) improve treatment responses by overcoming drug resistance.