VITAMIN E,OVARIAN CANCER AND FERTILITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 卵巢上皮癌是一种与排卵有关的疾病。在卵泡破裂过程中产生的遗传毒性/致突变的活性氧似乎会破坏卵巢表面上皮细胞的DNA，这些细胞在排卵过程中幸存下来；因此，一个没有修复或没有致力于凋亡的细胞(由于肿瘤抑制机制的缺陷)是潜在的问题。由于卵巢癌转移性疾病患者的预后很差，而且早期发现已被证明是难以捉摸的，因此探索前瞻性的化学预防方法是当务之急。这一分项目的主要目标是：1)确定上皮性卵巢癌病因学中潜在的致病机制(排卵因素)--目的是设计预防措施；以及2)通过克服耐药性来改善治疗反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Epithelial ovarian cancer is an ovulation-related disease. It appears that genotoxic/mutagenic reactive oxygen species generated during the mechanics of follicular rupture damage the DNA of ovarian surface epithelial cells that survive the insult of ovulation; a cell that is not repaired or does not become committed to apoptosis (because of a defective tumor suppressor mechanism) is hence potentially problematic. Since the prognosis for ovarian cancer patients with metastatic disease is so poor, and early detection has proven elusive, it is imperative that prospective methods of chemoprevention be explored. The primary objectives of this subproject are to: 1) identify prospective causative mechanisms (ovulatory factor) in the etiology of epithelial ovarian cancer - with the intention of devising prophylactic measures; and 2) improve treatment responses by overcoming drug resistance.