PLACENTOMAL VASCULAR ADAPTATIONS TO EARLY MATERNAL NUTRIENT RESTRICTION

胎盘血管对早期母体营养限制的适应

• 批准号: 7720520
• 负责人: STEPHEN P FORD
• 金额: $ 16.18万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720520
• 关键词: Adipose tissue; Birth; Blood Vessels; Body Composition; Child; Chronic; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Condition; Databases; Development; Diabetes Mellitus; Diet; Epidemic; Fetal Development; Fetal Growth; Fetal Tissues; Fetus; Funding; Grant; Health; Institution; Investigation; Knowledge; Laboratories; Lead; Life; Malnutrition; Modeling; Mothers; Nutrient; Obesity; Organ; Overnutrition; Pancreas; Physiological; Placenta; Pregnancy; Pregnant Women; Research; Research Personnel; Resources; Sheep; Skeletal Muscle; Source; Structure; System; Time; Tissues; United States; United States National Institutes of Health; Weight; Woman; child bearing; experience; fetal; insulin sensitivity; vasoactive agent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have extended our investigations during the course of the grant to study the impacts of maternal overnutrition as well as undernutrition on the placenta and fetus. The United States is experiencing an obesity epidemic which increasingly involves women of child bearing years. Increased pre-pregnancy maternal weight correlates with increased offspring weight and the potential for persistent and damaging consequences resulting from changes in body composition and developing tissue and organ function. The sheep is a powerful, unique model to study intrauterine environmental effects on placental and fetal development. There is an unparalleled fetal data base on physiological systems in this model from highly regarded laboratories worldwide. Clinical studies show developmental problems in the fetal pancreas in children born to obese pregnant women that lead to abnormalities of fetal growth and body composition. Offspring of obese mothers are more prone to chronic conditions such as obesity and diabetes that greatly impairs their life-time health. There is currently a lack of knowledge regarding the mechanisms whereby maternal obesity modifies placental and/or fetal development and function, or how this leads to health problems after birth. We have developed a model of maternal obesity in the sheep and are investigating diet induced changes in placental structure (i.e. composition, vascularity and placentomal type) and function (vascular sensitivity to vasoactive agents, placental nutrient transportors, and nutrient delivery to the fetus). Impact of maternal obesity on fetal pancreatic structure and function and fetal tissue (i.e. skeletal muscle, adipose, etc.) insulin sensitivity are also under investigation.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在赠款期间，我们扩大了我们的调查，以研究产妇营养过剩和营养不良对胎盘和胎儿的影响。美国正在经历一场肥胖流行病，越来越多的育龄妇女参与其中。怀孕前母体体重增加与后代体重增加以及身体组成和发育中的组织和器官功能变化导致的持久和破坏性后果的可能性相关。绵羊是研究子宫内环境对胎盘和胎儿发育影响的一种强大而独特的模型。有一个无与伦比的胎儿数据库的生理系统在这个模型从高度重视的实验室世界各地。临床研究表明，肥胖孕妇所生的孩子的胎儿胰腺发育问题，导致胎儿生长和身体成分异常。肥胖母亲的后代更容易患上慢性疾病，如肥胖和糖尿病，这极大地损害了他们的终身健康。目前缺乏关于母体肥胖改变胎盘和/或胎儿发育和功能的机制的知识，或者这如何导致出生后的健康问题。我们已经开发了一种绵羊母体肥胖模型，并正在研究饮食诱导的胎盘结构（即组成、血管分布和胎盘类型）和功能（血管对血管活性药物的敏感性、胎盘营养转运蛋白和向胎儿输送营养物质）的变化。母体肥胖对胎儿胰腺结构和功能以及胎儿组织（即骨骼肌、脂肪等）的影响胰岛素敏感性也在研究中。