VERTEBRATE PHYSIOLOGY AND NUTRITION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 蛋白激酶C(PKC)家族在许多不同的过程中起重要作用，包括细胞增殖和细胞周期停滞。在肿瘤组织中，PKC亚型的表达水平被认为是促进事件。许多饮食成分也被证明是促进肿瘤的。缺乏蛋白质或个别氨基酸的饮食会影响蛋白质合成和细胞分裂周期。然而，关于饮食影响和肠道组织中PKC表达之间的联系，如果有联系的话，人们知之甚少。我正在研究哺乳动物肠道组织在面临总蛋白或氨基酸缺乏的饮食挑战时，体外PKC同工酶的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Protein Kinase C (PKC) family of enzymes is important in many diverse processes including cellular proliferation and cell cycle arrest. Levels of expression of PKC isoforms have been linked as promotive events in neoplastic tissues. Many dietary components have also been shown to be tumor promoting. Diets deficient in protein or individual amino acids influence protein synthesis and cellular division cycles. However, little is known about the connection, if any, between dietary influences and PKC expression in intestine tissues. I am investigating the PKC isozyme response of mammalian intestinal tissues in vitro when confronted with a dietary challenge of total protein or amino acid deficiency.