CELL SIGNALING IN INTESTINAL EPITHELIAL CELLS FROM WOUND HEALING

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 研究目标 研究肠上皮细胞中某些蛋白激酶C家族酶的表达及其在伤口愈合中的作用。具体的重点将放在经典的异构体<$和<$和新的异构体<$。 检查皮质类固醇和溶血磷脂酸暴露对蛋白激酶C同工酶（<$、<$、<$）表达的影响及其对肠上皮伤口愈合率的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Research Goals Investigate the expression and role of some of the protein kinase C family of enzymes on wound healing in intestinal epithelial cells. Specific emphasis will be placed on the classical isoforms ¿ and ¿ and the novel isoform ¿. Examine the effect of corticosteroid and lysophosphatidic acid exposure on the expression of protein kinase C isozymes (¿, ¿, ¿) and their impact on rates of wound healing in intestinal epithelium.