CELL SIGNALING IN INTESTINAL EPITHELIAL CELLS FROM WOUND HEALING

伤口愈合中肠上皮细胞的细胞信号传导

• 批准号: 8360009
• 负责人: SHAWN D PEARCY
• 金额: $ 4.37万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360009
• 关键词: Adrenal Cortex Hormones; Enzymes; Epithelial Cells; Family; Funding; Goals; Grant; Intestines; Isoenzymes; Lysophospholipids; National Center for Research Resources; Nebraska; Principal Investigator; Protein Isoforms; Protein Kinase C; Research; Research Infrastructure; Resources; Role; Signal Transduction; Source; United States National Institutes of Health; Wound Healing; cost; functional genomics; intestinal epithelium; lysophosphatidic acid; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Research Goals Investigate the expression and role of some of the protein kinase C family of enzymes on wound healing in intestinal epithelial cells. Specific emphasis will be placed on the classical isoforms ¿ and ¿ and the novel isoform ¿. Examine the effect of corticosteroid and lysophosphatidic acid exposure on the expression of protein kinase C isozymes (¿, ¿, ¿) and their impact on rates of wound healing in intestinal epithelium.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 研究目标 研究一些蛋白激酶C家族酶在肠上皮细胞创伤愈合中的表达和作用。将特别强调经典的异构体和新的异构体。 检测糖皮质激素和溶血磷脂酸暴露对肠上皮细胞蛋白激酶C同工酶表达的影响及其对创面愈合率的影响。