VERTEBRATE PHYSIOLOGY AND NUTRITION

脊椎动物生理学和营养

• 批准号: 7960272
• 负责人: SHAWN D PEARCY
• 金额: $ 3.08万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960272
• 关键词: Amino Acids; Cell Cycle Arrest; Cell Proliferation; Computer Retrieval of Information on Scientific Projects Database; Diet; Dietary Component; Enzymes; Event; Family; Funding; Grant; In Vitro; Individual; Institution; Intestines; Isoenzymes; Link; Nebraska; Physiology; Process; Protein Biosynthesis; Protein Isoforms; Protein Kinase C; Proteins; Research; Research Personnel; Resources; Source; Tissues; United States National Institutes of Health; functional genomics; neoplastic; nutrition; response; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Protein Kinase C (PKC) family of enzymes is important in many diverse processes including cellular proliferation and cell cycle arrest. Levels of expression of PKC isoforms have been linked as promotive events in neoplastic tissues. Many dietary components have also been shown to be tumor promoting. Diets deficient in protein or individual amino acids influence protein synthesis and cellular division cycles. However, little is known about the connection, if any, between dietary influences and PKC expression in intestine tissues. I am investigating the PKC isozyme response of mammalian intestinal tissues in vitro when confronted with a dietary challenge of total protein or amino acid deficiency.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 蛋白激酶C（PKC）家族的酶在许多不同的过程中是重要的，包括细胞增殖和细胞周期停滞。PKC亚型的表达水平与肿瘤组织中的促进事件有关。许多饮食成分也被证明是促进肿瘤的。饮食中缺乏蛋白质或个别氨基酸会影响蛋白质合成和细胞分裂周期。然而，很少有人知道之间的联系，如果有的话，饮食的影响和PKC在肠组织中的表达。我正在研究哺乳动物肠道组织在体外的PKC同工酶反应时，面临的总蛋白质或氨基酸缺乏的饮食挑战。