Cellular Basis of Immunological and Neurological Disease

描述（由申请人提供）：在BRIN建立的网络基础上，INBRE建议扩大和发展夏威夷具有竞争力的生物医学研究能力。扩展将集中在三个主题项目，从免疫学，细胞生物学和发育生物学的角度探索免疫和神经疾病的细胞基础。每个项目都将由一名资历深厚的高级调查员领导，他将指导牵头机构和附属中学毕业文凭机构的初级调查员。这将延伸到该州的社区学院，参与的教师将与领先机构的知名研究人员合作。每个调查员-高级，初级和推广-将招募和指导本科生和研究生以及。发展将不仅集中在个人的研究事业，而且网络的整体方法，以竞争性研究。这涉及建立严格的标准和性能预期，再加上周到的指导，以帮助网络调查人员和学生满足这些具有挑战性的标准。从理论上讲，INBRE将 由四个主要核心组成：行政，研究，生物信息学和外联。行政 核心人员将提供全面的行政支助，包括维持网络的网站、评价工作以及培训和辅导讲习班和研讨会。研究核心将由三个主题研究项目组成，并由一名核心领导人负责确保项目协调。外展核心扩展到社区学院的研究推力通过促进研究和学生参与，通过与领导和学士学位机构的合作。生物信息学核心还将通过强调学术工作队伍的发展提供独特的机会。为了促进这一点，核心将被安置在夏威夷大学马诺阿信息和计算机科学系。

DESCRIPTION (provided by applicant): Building upon the network foundation established by BRIN, INBRE proposes to expand and to develop Hawaii's competitive biomedical research capacity. The expansion will center on three thematic projects exploring the cellular basis of immunological and neurological diseases from the perspective of immunology, cell biology, and developmental biology. Each project will be led by a well-established senior investigator who will mentor junior investigators at both the lead and the affiliated baccalaureate institutions. This will extend into the state's community colleges where participating faculty will collaborate with established researchers at the lead institution. Each investigator - senior, junior, and Outreach - will recruit and mentor undergraduate and graduate students as well. The development will concentrate on not only individual research careers but also the network's overall approach to competitive research. This involves the establishment of rigorous standards and performance expectations coupled with attentive mentoring to assist network investigators and students in meeting these challenging criteria. Organizationally, INBRE will consist of four major cores: Administrative, Research, Bioinformatics, and Outreach. The Administrative Core will provide overall administrative support, including maintenance of the network's web site, evaluation efforts, and training and mentoring workshops and seminars. The Research Core will be comprised of the three thematic research projects with a Core leader to ensure project coordination. The Outreach Core extends the research thrust into the community colleges by promoting research and student participation through collaborations with the lead and the baccalaureate institutions. The Bioinformatics Core will also provide unique opportunities by emphasizing academic work force development. To facilitate this, the Core will be housed within the University of Hawaii at Manoa's Department of Information and Computer Sciences.