Cellular Basis of Immunological and Neurological Disease

简介（由申请人提供）：在BRIN建立的网络基础上，INBRE提议扩大和发展夏威夷具有竞争力的生物医学研究能力。扩展将集中在三个专题项目上，从免疫学、细胞生物学和发育生物学的角度探索免疫和神经疾病的细胞基础。每个项目将由一名成熟的高级研究员领导，他将指导领导机构和附属学士学位机构的初级研究员。这将扩展到该州的社区学院，参与的教师将与领导机构的知名研究人员合作。每位研究员——高级、初级和外联——将招募并指导本科生和研究生。这一发展不仅将集中在个人的研究事业上，还将集中在该网络对竞争性研究的总体方法上。这包括建立严格的标准和绩效期望，以及细心的指导，以协助网络调查员和学生满足这些具有挑战性的标准。在组织上，英邦将

DESCRIPTION (provided by applicant): Building upon the network foundation established by BRIN, INBRE proposes to expand and to develop Hawaii's competitive biomedical research capacity. The expansion will center on three thematic projects exploring the cellular basis of immunological and neurological diseases from the perspective of immunology, cell biology, and developmental biology. Each project will be led by a well-established senior investigator who will mentor junior investigators at both the lead and the affiliated baccalaureate institutions. This will extend into the state's community colleges where participating faculty will collaborate with established researchers at the lead institution. Each investigator - senior, junior, and Outreach - will recruit and mentor undergraduate and graduate students as well. The development will concentrate on not only individual research careers but also the network's overall approach to competitive research. This involves the establishment of rigorous standards and performance expectations coupled with attentive mentoring to assist network investigators and students in meeting these challenging criteria. Organizationally, INBRE will consist of four major cores: Administrative, Research, Bioinformatics, and Outreach. The Administrative Core will provide overall administrative support, including maintenance of the network's web site, evaluation efforts, and training and mentoring workshops and seminars. The Research Core will be comprised of the three thematic research projects with a Core leader to ensure project coordination. The Outreach Core extends the research thrust into the community colleges by promoting research and student participation through collaborations with the lead and the baccalaureate institutions. The Bioinformatics Core will also provide unique opportunities by emphasizing academic work force development. To facilitate this, the Core will be housed within the University of Hawaii at Manoa's Department of Information and Computer Sciences.