THE INHIBITORY ROLE OF INTEGRIN ?5 IN ADIPOCYTE DIFFERENTIATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究旨在了解脂肪细胞分化，这是导致过量脂肪和肥胖的关键过程。虽然在脂肪细胞分化过程中观察到了细胞外基质和整合素受体表达的变化，但这些过程调控脂肪形成的能力在很大程度上还没有被探索。这项研究的总体目标是阐明整合素5的抗脂肪生成功能。这一目标将通过确定(1)整合素5表达的缺失是否促进脂肪细胞分化和肥胖；以及(2)整合素调节前脂肪细胞Rac活性的机制来实现。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is directed toward understanding adipocyte differentiation, a critical process that contributes to the development of excess adipose mass and obesity. While changes in the ECM and integrin receptor expression have been observed during adipocyte differentiation, the ability of these processes to regulate adipogenesis is largely unexplored. The overall GOAL of this proposed study is to elucidate the anti-adipogenic function of integrin ¿5. This goal will be accomplished by determining (1) whether the loss of integrin ¿5 expression promotes adipocyte differentiation and obesity; and (2) the mechanism whereby the ¿5 integrins regulates the Rac activity in preadipocytes.