Center for Computational Study of Biological Systems

生物系统计算研究中心

• 批准号: 6792647
• 负责人: JUN S LIU
• 金额: $ 62.32万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6792647
• 关键词: biochemical evolution; bioinformatics; biological signal transduction; biomedical resource; computational biology; computer system design /evaluation; experimental designs; functional /structural genomics

DESCRIPTION (provided by applicant): The broad research goals of this Pre-NPEBC (Planning grant for National Program of Excellence in Biocomputing) are as follows A) Involving computational biologists in the design of novel experiments employing newly available genomic technologies B) The development of methods to manage the large amount and diverse types of data, to develop analysis methods capable of utilization of multiple types information on the same biological system C) The development of novel computational approaches to analyze functional genomics data -- approaches that will actively utilize existing biological knowledge in the computation D) The implementation of robust and freely available software tools to support these activities, and facilitate wide distribution of useful data resources and analytical methods to the scientific community. We will form a multidisciplinary team composing of investigators from several schools across Harvard University, to study these issues in the context of three specific scientific areas mammalian cell signaling, the role of genetic instability in evolution, and developing new tools for computational biology There will be three Developmental Projects 1) functional genomics and bioinformatics approach to RAS signaling, 2) genome instability and evolution, 3) software environment for functional genomics. During the course of this Pre-NPEBC, we will also establish the organizational structure of the NPEBC, institute seminar series and visitor program in computational biology, and enhance the curriculum and expand the enrollment of the computational biology graduate program with the aim of eventually establishing a PhD degree program in Computational Biology.

描述（申请人提供）：这个Pre-NPEBC的广泛研究目标（生物计算国家卓越计划规划补助金）如下A）让计算生物学家参与采用新可用基因组技术的新颖实验的设计B）开发管理大量和不同类型数据的方法，开发能够利用同一生物系统的多种类型信息的分析方法C）开发新的计算方法来分析功能基因组学数据--D）实施强大和免费提供的软件工具，以支持这些活动，并促进向科学界广泛传播有用的数据资源和分析方法。 我们将组建一个由来自哈佛大学几个学院的研究人员组成的多学科团队，在三个特定科学领域的背景下研究这些问题哺乳动物细胞信号传导，遗传不稳定性在进化中的作用，以及开发计算生物学的新工具。将有三个发展项目1）RAS信号传导的功能基因组学和生物信息学方法，2）基因组不稳定性和进化，3）功能基因组学软件环境。 在此过程中预NPEBC，我们还将建立NPEBC的组织结构，研究所系列研讨会和访问计划在计算生物学，并加强课程和扩大计算生物学研究生课程的招生，最终建立在计算生物学博士学位课程的目的。