DNA REPAIR IN ALZHEIMER'S DISEASE

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our long-term goals are to investigate the mechanism of DNA repair in neurological degenerations. The objective of this research is to identify the role of Ogg1 in the development of AD. Our central hypothesis is that accumulation of oxo-dG in brains causes neuron cell death as an etiological factor for AD and that increase in Ogg1 may alleviate this damage. We have formulated the hypothesis based on our preliminary data showing oxo-dG and correspondent increase of Ogg1 in the brains of rabbits fed with cholesterol but not in the controls, a model for studying AD. Our research will result in novel data that may indicate novel therapeutic targets for this disease. Aim 1) To determine the main DNA lesion and its role in neural cell death in cholesterol induced AD like models. Aim 2) To investigate the roles of DNA repair protein Ogg1 in AD pathogenesis.