ORAL EFFECTS OF METHAMPHETAMINE USE: A STUDY OF "METH MOUTH"

甲基苯丙胺使用的口腔影响：“甲基苯丙胺之口”的研究

• 批准号: 7720800
• 负责人: Michele Carter Ravenel
• 金额: $ 1.59万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720800
• 关键词: American; Anterior; Behavior; Caring; Central Nervous System Stimulants; Chronic; Cleaved cell; Clinic; Clinical; Cocaine; Computer Retrieval of Information on Scientific Projects Database; Condition; Consumption; Dental; Dental Enamel; Dental Hygiene; Dental caries; Dental crowns; Dentists; Diet; Drug abuse; Drug usage; Exhibits; Frequencies; Funding; Grant; Gray unit of radiation dose; Habits; Health; Hour; Individual; Ingestion; Institution; Knowledge; Meth mouth; Methamphetamine; Methods; Mouth Diseases; Numbers; Oral; Oral health; Pattern; Periodontal Diseases; Population; Protocols documentation; Reporting; Research; Research Personnel; Resources; Salivary; Screening procedure; Services; Smoke; Source; South Carolina; Staining method; Stains; Structure; Surface; Surveys; Tooth Diseases; Tooth structure; Toothbrushing; United States; United States National Institutes of Health; Visit; Xerostomia; alcohol and other drug; insight; soft drink; teeth clenching; tooth surface; toothbrush

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Abuse of methamphetamine (meth), a potent central nervous system stimulant, is increasing in the United States. It is inexpensive, easy to make and produces an extended high (12 hours versus one hour for cocaine). It can be taken orally, snorted, injected or smoked. The 2003 National Survey on Drug Use and Health reported 12.3 million Americans had tried methamphetamine at least once. In South Carolina, the number of meth addicts seeking treatment in public clinics has increased 7-fold in the past 4 years (SC Department of Alcohol and Other Drug Abuse Services, 2006). Recently a small number of reports have described significant oral disease associated with the use of methamphetamine. "Meth mouth," as it is called, is characterized by accelerated, rampant caries involving the buccal smooth surfaces of the teeth and the interproximal surfaces of the anterior teeth. Additionally some methamphetamine addicts have developed enamel erosion and wear facets. Unfortunately current reports are limited and have not proven that methamphetamine is responsible for dental disease nor do they illuminate potential mechanisms for oral findings. To accomplish these aims we plan to conduct oral screening examinations and collect information on oral health knowledge and the oral hygiene practices of subjects addicted to methamphetamine. This information could serve to generate protocols for the management of oral disease in methamphetamine users. These studies will provide a baseline characterization of the oral health of individuals addicted to methamphetamine, insight into possible pathogenic mechanisms of methamphetamine on oral structures, and identify barriers to care in this population. The specific aims of this project are: Specific Aim 1: To describe patterns of dental caries, oral bacterial burden, periodontal involvement, wear patterns and salivary flow in chronic methamphetamine addicts Hypothesis: Chronic methamphetamine use is associated with a specific pattern of dental conditions including rampant caries, periodontal disease, grey-stained plaque, cracked teeth an oblique cleaving of clinical crowns, and xerostomia. Specific Aim 2: To investigate the relationship between oral health and (1) quantity, frequency and duration of meth use and (2) method of ingestion (i.e., orally, snorted, injected or smoked) of meth. Hypothesis: Oral disease will be positively correlated with quantity, frequenc and duration of meth use and will be found more frequently in addicts, who snort, smoke or orally consume meth. Specific Aim 3: To investigate the relationship between oral health in meth addicts and (1) oral health habits (i.e., regular tooth brushing and flossing; regular visits to dentist), (2) quantity of non-diet soft drinks consumed, and (3) frequency of grinding/clenching of the teeth. Hypothesis: Meth addicts who exhibit poor oral health habits, excessive consumption of non-diet soft drinks, and frequent grinding and clenching of teeth will show more pronounced dental disease than those without these behaviors. Specific Aim 4: To investigate meth addicts' knowledge of the relationship between meth use and dental disease Hypothesis: Meth addicts will have little knowledge of the relationship between meth use and dental disease.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 甲基安非他明（冰毒）是一种强效中枢神经系统兴奋剂，在美国滥用情况正在增加。它价格便宜，易于制造，并产生延长的高（12小时，而可卡因为1小时）。它可以口服，鼻吸，注射或吸烟。2003年全国毒品使用和健康调查报告称，1230万美国人至少尝试过一次甲基苯丙胺。在南卡罗来纳州，在过去4年中，到公共诊所寻求治疗的冰毒成瘾者人数增加了7倍（南卡罗来纳州酒精和其他药物滥用服务部，2006年）。 最近，少数报告描述了与使用甲基苯丙胺相关的严重口腔疾病。所谓的“冰毒口”，其特征在于涉及牙齿的颊侧光滑表面和前牙的邻间表面的加速的、猖獗的龋齿。此外，一些甲基苯丙胺成瘾者已经发展出牙釉质侵蚀和磨损方面。 不幸的是，目前的报告是有限的，并没有证明甲基苯丙胺是负责牙科疾病，也没有阐明潜在的机制，口腔的发现。为了实现这些目标，我们计划进行口腔筛查检查和收集信息的口腔健康知识和口腔卫生习惯的主题成瘾的甲基苯丙胺。这些信息可用于制定甲基苯丙胺使用者口腔疾病管理方案。 这些研究将提供甲基苯丙胺成瘾者口腔健康的基线特征，深入了解甲基苯丙胺对口腔结构的可能致病机制，并确定这一人群的护理障碍。 该项目的具体目标是： 具体目标1：描述慢性甲基苯丙胺成瘾者的龋齿模式、口腔细菌负荷、牙周受累、磨损模式和唾液流动 假设：长期使用甲基苯丙胺与一种特定的牙齿疾病模式有关，包括猖獗的龋齿、牙周病、灰斑、牙裂、临床牙冠的斜劈和口干症。 具体目标二：调查口腔健康与（1）使用冰毒的数量、频率和持续时间以及（2）摄入方法（即，口服、鼻吸、注射或吸食）冰毒。 假设：口腔疾病与使用冰毒的数量、频率和持续时间呈正相关，并且在吸毒、吸烟或口服冰毒的成瘾者中更常见。 具体目标3：调查冰毒成瘾者的口腔健康与（1）口腔健康习惯（即，定期刷牙和使用牙线;定期看牙医），（2）非减肥软饮料的摄入量，以及（3）磨牙/磨牙的频率。 假设：表现出不良口腔卫生习惯，过度消费非饮食软饮料，以及经常磨牙和咬牙的甲基苯丙胺成瘾者将比没有这些行为的人表现出更明显的牙科疾病。 具体目标4：调查冰毒成瘾者对冰毒使用和牙科疾病之间关系的认识 假设：冰毒成瘾者对冰毒使用和牙科疾病之间的关系知之甚少。