MICROBIAL ANALYSIS OF DENTAL PLAQUE SPECIES IN THE SEA ISLAND GULLAH POPULATION

海岛古拉群体牙菌斑物种的微生物分析

• 批准号: 7959788
• 负责人: Michele Carter Ravenel
• 金额: $ 0.71万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959788
• 关键词: African American; Age; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Decayed, Missing, and Filled Teeth; Dental Plaque; Dental caries; Diabetes Mellitus; Fibrinogen; Funding; General Population; Gingiva; Grant; Health Services Accessibility; Income; Individual; Institutes; Institution; Island; Literature; National Health and Nutrition Examination Survey; Oral; Oral health; Pathogenesis; Pilot Projects; Population; Protocols documentation; Research; Research Personnel; Resources; Sea; Smoking; Source; South Carolina; Tooth Diseases; United States National Institutes of Health; diabetic; glycemic control; microbial; oral pathogen

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In a recent study of dental caries in Gullah type 2 diabetics, no association was found between glycemic control of diabetes and dental caries both with and without adjustment for smoking, BMI, age and sex8. As expected the mean Decayed-Missing-Filled Tooth (DMFT) scores for the Gullah population was higher than that of the NHANES white population. However, the DMFT scores for the Gullah population was also higher (17.6¿6.9) as compared to both the 1989 NHANES Blacks (12.43¿0.14) and 1999 NHANES Blacks (11.07¿0.018) 4. Higher DMFT scores in the Gullah population as compared to the NHANES Black population suggests other factors in addition to income and access to care are involved in the pathogenesis of dental disease in the this population. One factor to consider is the difference in the oral microbial flora of the Gullah population. Similar studies of known oral pathogens have been conducted on the general population 9-14, but to date no such study on the Gullah population exists in the literature. The purpose of this pilot study is to characterize the oral microbial species in the supra-gingival dental plaque of Gullah type 2 diabetics using checkerboard DNA-DNA hybridization (Forsythe Institute). A modified checkerboard panel developed to study the more gram positive cariogenic species will be used 9. The percent of individuals that have selected bacterial species present will be compared to similar studies of non-Gullah type 2 diabetics14. Information gained will illuminate potential oral pathogens unique to the Gullah population as well as generate protocols for the management of dental disease in this population.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在最近的一项关于Gullah 2型糖尿病患者龋齿的研究中，在调整和不调整吸烟、BMI、年龄和性别的情况下，未发现糖尿病的血糖控制与龋齿之间存在关联8。 正如预期的那样，Gullah人群的平均龋坏-缺失-补牙（DMFT）评分高于NHANES白色人群。然而，与1989年NHANES黑人（12.43 <$0.14）和1999年NHANES黑人（11.07 <$0.018）相比，Gullah人口的DMFT得分也更高（17.6 <$6.9）。 与NHANES黑人人口相比，Gullah人口的DMFT分数较高，表明除了收入和获得护理之外，其他因素也参与了该人群牙病的发病机制。需要考虑的一个因素是格勒人口腔微生物植物群的差异。对普通人群9-14进行了已知口腔病原体的类似研究，但迄今为止，文献中还没有对Gullah人群进行此类研究。本初步研究的目的是使用棋盘DNA-DNA杂交（Forsythe Institute）表征Gullah 2型糖尿病患者龈上牙菌斑中的口腔微生物菌种。 将使用为研究革兰氏阳性致龋物种而开发的改良棋盘面板9。将选择存在细菌物种的个体的百分比与非Gullah 2型糖尿病的类似研究进行比较14。 所获得的信息将阐明Gullah人群特有的潜在口腔病原体，并为该人群的牙科疾病管理制定方案。