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• 批准号: 7722050
• 负责人: CHARLES EIGENBROT
• 金额: $ 0.55万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722050
• 关键词: Binding; Biological; Complex; Computer Retrieval of Information on Scientific Projects Database; Drug Design; Funding; Goals; Grant; Immune System Diseases; Institution; Knowledge; Lupus; Process; Research; Research Personnel; Resolution; Resources; Signal Transduction; Source; Specificity; Structure; Therapeutic; Time; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; United States National Institutes of Health; human TNF protein; insight; member; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of our research is to related to drug design, for which knowledge of biological structural information in paramount. Applications will include members of the tumor necrosis factor (TNF) superfamily and how they bind to different receptors. Determining the high-resolution structure of several complexes will give us insights into the specificity invloved in these processes, and allow determination of the core structural components of TNF-TNFR superfamily signaling, which may have therapeutic potential to control lupus and other auto-immune disorders.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的研究目标是与药物设计相关，对于药物设计而言，生物结构信息的知识至关重要。 应用程序将包括肿瘤坏死因子（TNF）超家族的成员以及它们如何与不同的受体结合。 确定几种复合物的高分辨率结构将使我们深入了解这些过程中的特异性，并允许确定TNF-TNFR超家族信号传导的核心结构组分，这可能具有控制狼疮和其他自身免疫疾病的治疗潜力。