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• 批准号: 8362135
• 负责人: CHARLES EIGENBROT
• 金额: $ 0.74万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362135
• 关键词: Binding; Biological; Complex; Drug Design; Funding; Goals; Grant; Immune System Diseases; Knowledge; Lupus; National Center for Research Resources; Principal Investigator; Process; Radiation; Research; Research Infrastructure; Resolution; Resources; Signal Transduction; Source; Specificity; Structure; Therapeutic; Tumor Necrosis Factor Receptor; Tumor Necrosis Factor-alpha; United States National Institutes of Health; cost; insight; member; receptor; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of our research is to related to drug design, for which knowledge of biological structural information in paramount. Applications will include members of the tumor necrosis factor (TNF) superfamily and how they bind to different receptors. Determining the high-resolution structure of several complexes will give us insights into the specificity involved in these processes, and allow determination of the core structural components of TNF-TNFR superfamily signaling, which may have therapeutic potential to control lupus and other auto-immune disorders.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们的研究目标是与药物设计相关，对于药物设计而言，生物结构信息的知识至关重要。 应用程序将包括肿瘤坏死因子（TNF）超家族的成员以及它们如何与不同的受体结合。 确定几种复合物的高分辨率结构将使我们深入了解这些过程中涉及的特异性，并允许确定TNF-TNFR超家族信号传导的核心结构组分，这可能具有控制狼疮和其他自身免疫疾病的治疗潜力。