ASCORBATE METABOLOME IN THE VITREOUS AND AQUEOUS HUMOR OF THE EYE

眼睛玻璃体和房水中的抗坏血酸代谢组

• 批准号: 7721559
• 负责人: DAVID BEEBE
• 金额: $ 1.05万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721559
• 关键词: Aqueous Humor; Cataract; Computer Retrieval of Information on Scientific Projects Database; Exposure to; Eye; Funding; Grant; Institution; Measures; Modeling; Nuclear; Oxygen; Rate; Reaction; Relative (related person); Research; Research Personnel; Resources; Retina; Source; United States National Institutes of Health; age related; ascorbate; lens

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Summary: We wish to analyze the metabolites resulting from the reaction of ascorbate with oxygen in model reactions and in the vitreous and aqueous humors of the eye. We recently found that the reaction of ascorbate (and, possibly, its metabolites) with oxygen protect the lens against excessive exposure to oxygen from the retina. Excess exposure to oxygen is likely to be the primary cause of nuclear cataracts, the most common type of age-related cataracts. Measuring the products of this reaction will allow us to determine the relative rate of ascorbate degradation in the eye.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 项目摘要：我们希望分析模型反应以及眼睛玻璃体和房水中抗坏血酸与氧气反应产生的代谢物。我们最近发现，抗坏血酸（可能还有其代谢物）与氧气的反应可以保护晶状体免受视网膜过度暴露于氧气的影响。过度接触氧气可能是核性白内障的主要原因，核性白内障是最常见的年龄相关性白内障类型。测量该反应的产物将使我们能够确定抗坏血酸在眼睛中降解的相对速率。