ROLE OF YPT GTPASES IN INTRACELLULAR TRAFFICKING

YPT GTASE 在细胞内贩运中的作用

• 批准号: 7723725
• 负责人: Nava Segev
• 金额: $ 1.95万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723725
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Fluorescence Resonance Energy Transfer; Funding; Grant; Guanosine Diphosphate; Guanosine Triphosphate; Guanosine Triphosphate Phosphohydrolases; Institution; Mediating; Purpose; Research; Research Personnel; Resources; Role; Secretory Vesicles; Source; United States National Institutes of Health; mouse Gdi2 protein; rab GTP-Binding Proteins; trafficking; trans-Golgi Network

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ypt/Rab GTPases are conserved key regulators of all steps of intracellular trafficking. They act by cycling between the GTP "on" and the GDP "off" states. This cycling is regulated in turn by upstream regulators: GEFs and GAPs. At the "on" state Ypt/Rabs interact with effectors that mediate vesicular transport. We focus on Ypt31/32, Ypt/Rab GTPases responsible for secretory vesicle exit from trans-Golgi network, looking for their effectors and their mode of action on these effectors, as well as their upstream regulators. We would like to use FRET for these purposes.

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