ANTIGEN INVOLVED IN ATYPICAL BINDING OF CHRONIC LYMPHOCYTIC LEUKEMIA CELLS

参与慢性淋巴细胞白血病细胞非典型结合的抗原

• 批准号: 7723005
• 负责人: ALICE A ALEXANDER
• 金额: $ 0.13万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723005
• 关键词: Antigens; B-Lymphocytes; Binding; Bladder; Breast; Cell Line; Cells; Chronic Lymphocytic Leukemia; Colon; Computer Retrieval of Information on Scientific Projects Database; Funding; Genus Cola; Grant; Hematopoietic; Human; Hybridomas; Immunoglobulin M; Infiltration; Institution; Mediating; Mus; Organ; Patients; Prostate; Research; Research Personnel; Resources; Site; Source; United States National Institutes of Health; antigen binding; design; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic lymphocytic leukemia (CLL) is characterized by an accumulation of monoclonal B lymphocytes in the hematopoietic organs. In a few cases, CLL cells accumulate in a single atypical site; the mechanism for this unusual distribution has not been studied previously. CLL cells from patients with heavy prostate infiltration were found to bind to cultured prostate cells, but not to colon, breast, or bladder cells. Fusion CLL cells with a mouse-human heteromyeloma cell line, hybridomas designed to express the authentic CLL monoclonal IgM, bind specifically to prostate cells. The experiments are designed to characterize the antigen bound to the CLL IgM, which is indicated to be the compound mediating this atypical prostate infiltration.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 慢性淋巴细胞白血病 (CLL) 的特征是单克隆 B 淋巴细胞在造血器官中积聚。在少数情况下，CLL 细胞聚集在单个非典型部位；以前尚未研究过这种不寻常分布的机制。研究发现，来自前列腺严重浸润患者的 CLL 细胞与培养的前列腺细胞结合，但不与结肠、乳腺或膀胱细胞结合。将 CLL 细胞与小鼠-人异源骨髓瘤细胞系融合，这种杂交瘤旨在表达真正的 CLL 单克隆 IgM，与前列腺细胞特异性结合。这些实验旨在表征与 CLL IgM 结合的抗原，该抗原被表明是介导这种非典型前列腺浸润的化合物。