ANTIGEN INVOLVED IN ATYPICAL BINDING OF CHRONIC LYMPHOCYTIC LEUKEMIA CELLS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 慢性淋巴细胞性白血病(CLL)的特征是单克隆性B淋巴细胞在造血器官中聚集。在少数情况下，CLL细胞聚集在一个非典型部位；这种不寻常分布的机制以前还没有研究过。来自重度前列腺癌患者的CLL细胞被发现与培养的前列腺细胞结合，但不与结肠、乳房或膀胱细胞结合。融合的CLL细胞与鼠-人异种骨髓瘤细胞系，杂交瘤细胞株，旨在表达真正的CLL单抗IgM，特异性结合到前列腺细胞。这些实验旨在鉴定与CLL IgM结合的抗原，它被认为是介导这种非典型前列腺癌侵袭的化合物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic lymphocytic leukemia (CLL) is characterized by an accumulation of monoclonal B lymphocytes in the hematopoietic organs. In a few cases, CLL cells accumulate in a single atypical site; the mechanism for this unusual distribution has not been studied previously. CLL cells from patients with heavy prostate infiltration were found to bind to cultured prostate cells, but not to colon, breast, or bladder cells. Fusion CLL cells with a mouse-human heteromyeloma cell line, hybridomas designed to express the authentic CLL monoclonal IgM, bind specifically to prostate cells. The experiments are designed to characterize the antigen bound to the CLL IgM, which is indicated to be the compound mediating this atypical prostate infiltration.