ANTIGEN INVOLVED IN ATYPICAL BINDING OF CHRONIC LYMPHOCYTIC LEUKEMIA CELLS

参与慢性淋巴细胞白血病细胞非典型结合的抗原

• 批准号: 7369262
• 负责人: ALICE A ALEXANDER
• 金额: $ 0.16万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369262
• 关键词: ANTIGEN; INVOLVED; ATYPICAL; BINDING; CHRONIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic lymphocytic leukemia (CLL) is characterized by an accumulation of monoclonal B lymphocytes in the hematopoietic organs. In a few cases, CLL cells accumulate in a single atypical site; the mechanism for this unusual distribution has not been studied previously. CLL cells from patients with heavy prostate infiltration were found to bind to cultured prostate cells, but not to colon, breast, or bladder cells. Fusion CLL cells with a mouse-human heteromyeloma cell line, hybridomas designed to express the authentic CLL monoclonal IgM, bind specifically to prostate cells. The experiments are designed to characterize the antigen bound to the CLL IgM, which is indicated to be the compound mediating this atypical prostate infiltration.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。慢性淋巴细胞性白血病(CLL)的特征是单克隆性B淋巴细胞在造血器官中聚集。在少数情况下，CLL细胞聚集在一个非典型部位；这种不寻常分布的机制以前还没有研究过。来自重度前列腺癌患者的CLL细胞被发现与培养的前列腺细胞结合，但不与结肠、乳房或膀胱细胞结合。融合的CLL细胞与鼠-人异种骨髓瘤细胞系，杂交瘤细胞株，旨在表达真正的CLL单抗IgM，特异性结合到前列腺细胞。这些实验旨在鉴定与CLL IgM结合的抗原，它被认为是介导这种非典型前列腺癌侵袭的化合物。