ANTIGEN INVOLVED IN ATYPICAL BINDING OF CHRONIC LYMPHOCYTIC LEUKEMIA CELLS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic lymphocytic leukemia (CLL) is characterized by an accumulation of monoclonal B lymphocytes in the hematopoietic organs. In a few cases, CLL cells accumulate in a single atypical site; the mechanism for this unusual distribution has not been studied previously. CLL cells from patients with heavy prostate infiltration were found to bind to cultured prostate cells, but not to colon, breast, or bladder cells. Fusion CLL cells with a mouse-human heteromyeloma cell line, hybridomas designed to express the authentic CLL monoclonal IgM, bind specifically to prostate cells. The experiments are designed to characterize the antigen bound to the CLL IgM, which is indicated to be the compound mediating this atypical prostate infiltration.