CRYSTAL STRUCTURE OF COMPLEX OF CRALBP WITH 11-CIS-RETINAL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 细胞视黄醛结合蛋白（CRALBP）的结构研究 CRALBP是在视网膜的色素上皮中表达的细胞溶质蛋白，其充当11-顺式-视网膜的储库，11-顺式-视网膜是视紫红质（主要视色素）的辅因子。 它是CRAL-TRIO蛋白家族的一部分，与疏水配体结合并作为转移因子。 CRALBP的突变与导致失明的遗传性视网膜变性有关。 待研究的晶体是与11-顺式-视黄醛结合的人类蛋白质。该蛋白的结构将有助于更好地理解CRALBP的功能，并可能为CRAL-TRIO蛋白大家族提供见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Structural Studies of Cellular Retinaldehyde Binding Protein (CRALBP) CRALBP is a cytosolic protein expressed in the pigmented epithelium of the retina that serves as a reservoir of 11-cis-retinal, a cofactor of rhodopsin, the primary visual pigment. It is part of the CRAL-TRIO family of proteins, which bind to hydrophobic ligands and act as transfer factors. Mutations in CRALBP have been associated with a hereditary form of retinal degeneration leading to blindness. The crystals to be studied are of the human protein bound to 11-cis-retinal. The structure of this protein will lead to a better understanding of the function of CRALBP, and may provide insight to the large family of CRAL-TRIO proteins.