ROLE OF CARDIAC MICROSTRUCTURE IN ARRHTHMIA GENERATION AND DEFIBRILATION IN THE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尽管除颤治疗很重要，但对电击阻止危及生命的心律失常的机制的了解仍然不完整。虽然最近的实验进展为组织对电击的反应提供了新的特征，但由于目前的实验技术无法足够准确地解决限于脑室深度的电行为，对除颤成功和失败的机制探讨受到阻碍。这项研究的总体目标是，通过使用逼真的3D计算机模拟，使人们对导致休克失败的心脏中的休克后事件有一个新的理解。目前的模型没有包含解剖微异质性，这可能会起到重要作用。具体地说，在这个项目中，我们在心脏微结构的双项模型中研究了“等电窗”的潜在机制，即在失败的电击后的第一次震后激活之前的静止期。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the importance of defibrillation therapy, understanding of mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete. While recent experimental advances have provided new characterizations of tissue responses to shocks, mechanistic inquiry into the success and failure of defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles. The overall objective of this study is, by employing realistic 3D computer simulations, to bring a new level of understanding of the post-shock events in the heart that lead to the failure of the shock. Current models do not incorporate anatomical microheterogeneities, which could play an important role. Specifically, in this project we examine, in bidomain models of cardiac micro-structure, mechanisms underlying the ``isoelectric window", the quiescent period often preceding the first postshock activation following failed shocks.