A DIFFUSION TENSOR TRACTOGRAPHY STUDY OF YOUNG MALE CHILDREN WITH FRAGILE X

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言： 脆性X智力低下基因(FMR1)的突变与一系列认知和行为缺陷有关，其中之一是无法进行有效的抑制性控制。连接尾状核和前额叶皮质的腹侧额纹状体通路与认知和行为抑制有关。扩散张量成像(DTI)纤维束成像提供了研究活体人脑内白质通路的结构完整性的能力。 具体目标： 研究腹侧额纹状体通路的结构完整性。 方法： 在这项研究中，我们使用DTI研究了患有脆性X的年轻男性儿童的腹侧额纹状体通路的结构完整性，典型的发育和发育延迟年龄匹配的对照组(1.58±3.64岁)。为了提高解剖学的特异性，我们使用了一种方法，将从尾状核腹侧投射到腹侧前额叶皮质的纤维与从尾状核背侧投射到前额叶背外侧的纤维分离。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Mutation of the Fragile X Mental Retardation gene (FMR1) is associated with a host of cognitive and behavioral deficits, one of which is the inability to exercise effective inhibitory control. The ventral frontostriatal pathway, linking the caudate nucleus with the ventral prefrontal cortex, is known to be involved in the inhibition of cognitions and behaviors. Diffusion Tensor Imaging (DTI) tractography provides the ability to investigate the structural integrity of white matter pathways within the living human brain. Specific Aims: To investigate the structural integrity of the ventral frontostriatal pathway. Methods: In this study, we used DTI to investigate the structural integrity of the ventral frontostriatal pathway in a sample of young male children with Fragile X, Typically Developing and Developmentally Delayed age matched control groups (1.58  3.64 years). In order to improve anatomical specificity, we used an approach that dissociates fibers that project from the ventral portion of the caudate nucleus to the ventral prefrontal cortex from those that project from the dorsal portion of the caudate nucleus to the dorsolateral prefrontal cortex.