ASYNCHRONY OF BOLD SIGNAL ACROSS BRAIN REGIONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 简介： 通过fMRI测量的神经激活的血流动力学反应在不同的脑区域具有不同的特征。以前的工作表明，不同的大脑区域或层可以表现出不同的血流动力学反应，但没有系统的研究在整个大脑中的这种差异。 具体目标： 为了研究BOLD信号的时间方面，即BOLD信号在不同脑区的超前-滞后性， 研究方法： 我们使用相关图来量化每两个大脑区域之间的领先或滞后，从90个区域中预定义的解剖自动标记在一个大的数据集，约1000名受试者跨越10个不同的功能磁共振成像实验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: The hemodynamic response of neural activation as measured by fMRI has different characteristics across different brain regions. Previous work has shown that different brain regions or layers can show different hemodynamic response, but there is no systematic investigation of such difference across the entire brain. Specific Aims: To study the temporal aspect of BOLD signal; that is, the asynchrony (lead-lag) of BOLD signal across different brain regions, Methods: We used correlogram to quantify the lead or lag between every two brain regions from 90 regions predefined in Anatomical Automatic Labeling in a large dataset of about 1000 subjects crossing 10 different fMRI experiments.