PROTON ECHO PLANAR SPECROSCOPY IN HUMAN BRAIN AT 3 AND 4 TESLA

3 和 4 特斯拉时人脑中的质子回波平面光谱

• 批准号: 7721382
• 负责人: Stefan Posse
• 金额: $ 1.78万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721382
• 关键词: Aspartate; Binding; Brain; Choline; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Creatine; Data; Funding; Glutamates; Glutamine; Glutathione; Grant; Human; Inositol; Institution; Maps; Methodology; Multicenter Studies; Noise; Peripheral; Phosphocreatine; Protons; Range; Relaxation; Reporting; Research; Research Personnel; Resolution; Resources; Scalp structure; Scanning; Signal Transduction; Slice; Source; Time; United States National Institutes of Health; Water; attenuation; gamma-Aminobutyric Acid; gray matter; macromolecule; phosphoethanolamine; spectroscopic imaging; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this multicenter study, 2D spatial mapping of J-coupled resonances at 3T and 4T was performed using short-TE (15 ms) proton echo-planar spectroscopic imaging (PEPSI). Water-suppressed (WS) data were acquired in 8.5 min with 1-cm3 spatial resolution from a supraventricular axial slice. Optimized outer volume suppression (OVS) enabled mapping in close proximity to peripheral scalp regions. Constrained spectral fitting in reference to a non-WS (NWS) scan was performed with LCModel using correction for relaxation attenuation and partial-volume effects. The concentrations of total choline (tCho), creatine + phosphocreatine (Cr+PCr), glutamate (Glu), glutamate + glutamine (Glu+Gln), myo-inositol (Ins), NAA, NAA+NAAG, and two macromolecular resonances at 0.9 and 2.0 ppm were mapped with mean Cramer-Rao lower bounds (CRLBs) between 6% and 18% and 150-cm3 sensitive volumes. Aspartate, GABA, glutamine (Gln), glutathione (GSH), phosphoethanolamine (PE), and macromolecules (MMs) at 1.2 ppm were also mapped, although with larger mean CRLBs between 30% and 44%. The CRLBs at 4T were 19% lower on average as compared to 3T, consistent with a higher signal-to-noise ratio (SNR) and increased spectral resolution. Metabolite concentrations were in the ranges reported in previous studies. Glu concentration was significantly higher in gray matter (GM) compared to white matter (WM), as anticipated. The short acquisition time makes this methodology suitable for clinical studies

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在这项多中心研究中，使用短TE（15 ms）质子回波平面光谱成像（PEPSI）在3 T和4 T下进行J耦合共振的2D空间标测。水抑制（WS）的数据在8.5分钟内获得1立方厘米的空间分辨率从室上性轴向切片。优化的外部体积抑制（OVS）使映射接近周边头皮区域。使用LCModel对弛豫衰减和部分容积效应进行校正，对非WS（NWS）扫描进行约束光谱拟合。总胆碱（tCho）、肌酸+磷酸肌酸（Cr+PCr）、谷氨酸（Glu）、谷氨酸+谷氨酰胺（Glu+Gln）、肌醇（Ins）、NAA、NAA+NAAG的浓度以及0.9和2.0 ppm的两个大分子共振的浓度被绘制，平均克拉默-拉奥下限（CRLB）在6%和18%之间，敏感体积为150-cm 3。还绘制了1.2 ppm的天冬氨酸、GABA、谷氨酰胺（Gln）、谷胱甘肽（GSH）、磷酸乙醇胺（PE）和大分子（Glu），尽管平均CRLB较大，介于30%和44%之间。与3 T相比，4 T下的CRLB平均低19%，与较高的信噪比（SNR）和增加的光谱分辨率一致。代谢物浓度在既往研究报告的范围内。正如预期，灰质（GM）中的Glu浓度显著高于白色物质（WM）。短的采集时间使该方法适合于临床研究