SPHINGOLIPID METABOLISM IN THE RETINA

视网膜中的鞘脂代谢

• 批准号: 7722638
• 负责人: ALFRED Harrison MERRILL
• 金额: $ 0.38万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-08 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722638
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diabetic Retinopathy; Disease Resistance; Funding; Grant; Institution; Insulin Resistance; Metabolism; Neurons; Pathology; Research; Research Personnel; Resources; Retina; Retinal; Source; Sphingolipids; United States National Institutes of Health; neuron loss

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dysregulated sphingolipid metabolism causes neuronal cell death and is associated with insulin resistance and diseases. Thus, we hypothesize that diabetes-induced changes in retinal sphingolipid metabolism may contribute to neuronal pathologies in diabetic retinopathy.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 神经鞘脂代谢失调会导致神经细胞死亡，并与胰岛素抵抗和疾病有关。 因此，我们假设糖尿病引起的视网膜鞘脂代谢的变化可能对神经细胞起作用。 糖尿病视网膜病变的病理学。