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CELL SURFACE GLYCOSPHINGOLIPIDS SSEA-3 AND SSEA-4

CELL SURFACE GLYCOSPHINGOLIPIDS SSEA-3 AND SSEA-4
细胞表面糖脂 SSEA-3 和 SSEA-4
批准号:
7602785
负责人:
ALFRED Harrison MERRILL
金额:
$0.62万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-07-01 至 2008-06-30

项目摘要

项目成果

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中文摘要
翻译
该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者(PI)可能从另一个NIH来源获得主要资金, 因此可以在其他CRISP条目中表示。列出的机构是 中心,不一定是研究者的机构。 多能细胞可以从人胚泡中分离出来,并以自我更新、未分化、 胚胎干细胞(hESC)。它们是体外人类发育的有价值的模型,并且是实质性研究的焦点。 旨在为细胞疗法产生分化群体的研究。细胞外标记物 用于表征hESC的主要是蛋白聚糖或鞘脂上的碳水化合物表位,例如阶段- 特异性胚胎抗原(SSEA)-3和 4. SSEA-3的表达和 4在植入前受到严格调节 开发和hESC。虽然这可能意味着在未分化细胞中的分子功能,但它还没有被证实。 实验测试。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pluripotent cells can be isolated from the human blastocyst and maintained in culture as self-renewing, undifferentiated, embryonic stem cells (hESCs). They are a valuable model of human development in vitro, and are the focus of substantial research aimed at generating differentiated populations for cellular therapies. The extracellular markers that have been used to characterize hESCs are primarily carbohydrate epitopes on proteoglycans or sphingolipids, such as the stage- specific embryonic antigens (SSEA)-3 and 4. The expression of SSEA-3 and 4 is tightly regulated during preimplantation development and on hESCs. While this might imply a molecular function in undifferentiated cells, it has not yet been tested experimentally.
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INVESTIGATION OF 1-DEOXYDIHYDROCERAMIDE BIOSYNTHESIS BY MAMMALIAN CELLS
  • 批准号:
    8365570
  • 项目类别:
  • 资助金额:
    $1.54万
  • 财政年份:
    2011
  • 负责人:
    ALFRED Harrison MERRILL
  • 依托单位:
1-DEOXY-SPHINGOID BASE AND 1-DEOXYDIHYDROCER BIOSYNTHESIS IN MAMALS
  • 批准号:
    8170944
  • 项目类别:
  • 资助金额:
    $1.75万
  • 财政年份:
    2010
  • 负责人:
    ALFRED Harrison MERRILL
  • 依托单位:
Chemoprevention via modulation of autophagy by sphingolipids
  • 批准号:
    7860733
  • 项目类别:
  • 资助金额:
    $7.17万
  • 财政年份:
    2009
  • 负责人:
    ALFRED Harrison MERRILL
  • 依托单位:
Chemoprevention via modulation of autophagy by sphingolipids
  • 批准号:
    7590890
  • 项目类别:
  • 资助金额:
    $7.17万
  • 财政年份:
    2009
  • 负责人:
    ALFRED Harrison MERRILL
  • 依托单位:
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